Clinical trialNCT04571619CompletedPhase 2Interventional

HOPE Consortium Trial to Reduce Pain and Opioid Use in Hemodialysis

SponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Enrollment643Chronic PainEnd Stage Renal DiseaseOpioid Dependence

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

HOPE is a randomized clinical trial that will evaluate approaches to reducing pain and opioid use among patients with chronic pain who are receiving maintenance hemodialysis for end-stage renal disease. The hypothesis is that pain coping skills training will be effective at reducing pain and opioid use, and that buprenorphine will be acceptable and tolerable as an approach to managing physical dependence on opioids in this patient population.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Laura Dember, MD
University of Pennsylvania
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

16 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

West Haven Va Healthcare System
West Haven, Connecticut, United States
University of Illinois at Chicago
Chicago, Illinois, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
Hennepin County Medical Center
Minneapolis, Minnesota, United States
University of New Mexico
Albuquerque, New Mexico, United States
New York University
New York, New York, United States
Rogosin Institute
New York, New York, United States
Va Ny Harbor Healthcare System
New York, New York, United States
Durham Va Healthcare System
Durham, North Carolina, United States
Va Portland Healthcare System
Portland, Oregon, United States
University of Pennsylvania
Philadelphia, Pennsylvania, United States
University of Pittsburgh
Pittsburgh, Pennsylvania, United States
Vanderbilt University Medical Center
Nashville, Tennessee, United States
Dallas Va Medical Center
Dallas, Texas, United States
University of Washington
Seattle, Washington, United States
West Virginia University
Morgantown, West Virginia, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Buprenorphine →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 3 Jan 2021
Primary completion: 21 Dec 2023
Completion: 31 May 2024
Last update posted: 13 Jan 2025
Registered enrollment: 643
Registry id: NCT04571619

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.