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Clinical trialNCT04586244TerminatedPhase 2Interventional

An Umbrella Study to Determine the Safety and Efficacy of Various Monotherapy or Combination Therapies in Neoadjuvant Urothelial Carcinoma

SponsorIncyte CorporationEnrollment30Urothelial Carcinoma
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is a multicenter, open-label, randomized, Phase 2 umbrella study of various neoadjuvant treatment combinations in participants who have muscle-invasive urothelial carcinoma of the bladder and are cisplatin-ineligible or refusing cisplatin therapy and awaiting radical cystectomy.

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

12 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

France
  • Hopital Europeen Georges Pompidou (hegp)

    Paris, France

  • Hospital Saint Louis

    Paris, France

  • Institut Gustave Roussy

    Villejuif, France

Italy
  • Istituto Tumori Giovanni Paolo Ii Irccs Ospedale Oncologico Bari

    Bari, Italy

  • L Azienda Ospedaliero-Universitaria Di Bologna Policlinico S. Orsola - Malpighi

    Bologna, Italy

  • Istituto Di Ricovero E Cura A Carattere Scientifico (irccs) Ospedale San Raffaele

    Milan, Italy

  • Universita Campus Bio Medico Di Roma

    Roma, Italy

  • Azienda Ospedaliera Universitaria Integrata Verona (ospedale Borgo Roma)

    Verona, Italy

United States
  • University of Iowa

    Iowa City, Iowa, United States

  • University of Cincinnati

    Cincinnati, Ohio, United States

  • Ohio State University Medical Center Division of H

    Columbus, Ohio, United States

  • Oregon Health & Science University

    Portland, Oregon, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

INCAGN02385INCAGN02390EpacadostatRetifanlimab →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
14 Jan 2022
Primary completion
29 Jan 2024
Completion
29 Jan 2024
Last update posted
30 Oct 2025
Registered enrollment
30
Registry id
NCT04586244

Cross-registrations

EU-CTR / CTIS (EudraCT)2020-002244-23

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.