Clinical trialNCT04613921RecruitingObservational

Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs

SponsorEuropean Foundation for Study of Chronic Liver FailureEnrollment3,000Acute-On-Chronic Liver FailureLiver CirrhosisLiver DiseasesLiver Transplant; Complications

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Management of ACLF is mainly supportive. The poor outcomes lead physicians to consider liver transplantation as an option, even if controversial. In sicker recipients, LT results in immediate survival, but poor medium-term survival rates in some studies. The scarcity of deceased donors obliges to maximize LT success. Alternative strategies, as living-donor LT, should be explored. LDLT has impressive results in Eastern centers, but it is restrained in Western countries, due to potential life-threatening complications in the donor.

clinicaltrials.gov ↗

Investigators

No overall officials are registered on this study record. Site-level investigators, where published, appear with their sites below. Why? →

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

106 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Argentina

Austral University Hospital
Buenos Aires, Argentina
Manuel Mendizábal, md
Recruiting
Hospital Alemán
Buenos Aires, Argentina
Recruiting
Italian Hospital in Buenos Aires
Buenos Aires, Argentina
Adrián Gadano, MD
Recruiting

Australia

Austin Hospital
Heidelberg, Australia
Recruiting
Sir Charles Gairdner Hospital
Nedlands, Australia
Suspended
Royal Prince Alfred Hospital
Sydney, Australia
Recruiting

Austria

Medical University of Vienna, Department of Transplant Surgery
Vienna, Austria
Andreas RosenstinglGabriela Berlakovitch
Recruiting

Belgium

Cub Erasme Hospital
Brussels, Belgium
Recruiting
Ghent University Hospital
Ghent, Belgium
Hans Van VlierbergheXavier Verhelst
Recruiting
Uz Leuven
Leuven, Belgium
Frederik NevensWim Laleman
Recruiting

Brazil

Walter Cantídio University Hospital
Fortaleza, Brazil
Recruiting
Irmandade Santa Casa de Misericórdia de Porto Alegre
Porto Alegre, Brazil
Recruiting
Hospital Das Clínicas Da Universidade de São Paulo
São Paulo, Brazil
Recruiting

Canada

University of Alberta
Edmonton, Canada
Recruiting
University of Toronto, Multiorgan Transplant Program
Toronto, Canada
Recruiting

Colombia

Pablo Tobón Uribe Hospital
Medellín, Colombia
Recruiting

Czechia

Institute for Clinical and Experimental Medicine
Prague, Czechia
Eva KieslichováPavel Taimr
Not, yet, recruiting

France

Aphp Beaujon
Clichy, France
Recruiting
Aphp Henri Mondor
Créteil, France
Recruiting
Hôpital de la Croix-Rousse
Lyon, France
Recruiting
Chu Montpellier-Hôpital Saint Eloi
Montpellier, France
Recruiting
Aphp Hôpitaux Universitaires Pitié Salpêtrière
Paris, France
Recruiting
Chu Rennes, Hôpital de Pontchaillou
Rennes, France
Recruiting
Hautepièrre Hospital, Service de Réanimation Médicale
Strasbourg, France
Recruiting
Trousseau Hospital,
Tours, France
Recruiting
Hôpital Paul Brousse
Villejuif, France
Recruiting

Germany

University Hospital Regensburg
Regensburg, Eastern Bavaria, Germany
Martina Müller-Schilling, MD
Not, yet, recruiting
Universitätsklinikum Schleswig-Holstein (uksh)
Kiel, Schleswig-Holstein, Germany
Thomas Becker, Prof
Not, yet, recruiting
University Hospital Aachen
Aachen, Germany
Suspended
Charité University Hospital
Berlin, Germany
Recruiting
Goethe University Clinic
Frankfurt, Germany
Not, yet, recruiting
University Medical Center, Hamburg Eppendorf
Hamburg, Germany
Recruiting
Hannover Medical School
Hanover, Germany
Not, yet, recruiting
University Hospital Heidelberg
Heidelberg, Germany
Not, yet, recruiting
Jena University Hospital
Jena, Germany
Suspended
Universitätsklinikum Schleswig-Holstein (uksh)
Kiel, Germany
Recruiting
Leipzig University Hospital
Leipzig, Germany
Thomas Berg
Not, yet, recruiting
University Hospital Mainz
Mainz, Germany
Suspended
Lmu Großhadern
Munich, Germany
Suspended
Ukm Muenster
Münster, Germany
Recruiting

66 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 8 Jul 2021
Primary completion: 31 Dec 2026
Completion: 31 Dec 2026
Last update posted: 20 Oct 2025
Registered enrollment: 3,000
Registry id: NCT04613921

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.