Clinical trialNCT04614662CompletedInterventional

Symptom Screening Linked to Care Pathways

SponsorThe Hospital for Sick ChildrenEnrollment445Pediatric CancerQuality of Life

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Most children with cancer survive because they are given intensive treatments, but unfortunately, these treatments are associated with distressing symptoms. To address this problem, we developed the Symptom Screening in Pediatrics Tool (SSPedi) so that children receiving cancer treatments can communicate their bothersome symptoms, and Supportive care Prioritization, Assessment and Recommendations for Kids (SPARK), a web-based application that links identified symptoms to supportive care guidelines for symptom management. To establish that these tools improve the lives of children newly diagnosed with cancer, we will conduct a trial that randomizes 20 pediatric cancer institutions and measures the impact of three times weekly symptom screening, symptom feedback to healthcare providers and the development of care pathways for symptom management to improve total symptom burden, fatigue and quality of life.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Allison Grimes, MD
The University of Texas Health Science Center at San Antonio
Principal Investigator
clinicaltrials.gov ↗
Laura Lee Dupuis, RPh, PhD
The Hospital for Sick Children
Principal Investigator
clinicaltrials.gov ↗
Lillian Sung, MD, PhD
The Hospital for Sick Children
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

21 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

the Hospital for Sick Children
Toronto, Ontario, Canada

United States

Phoenix Children'S Hospital
Phoenix, Arizona, United States
Children'S Hospital Los Angeles
Los Angeles, California, United States
the Leland Stanford Junior University
Redwood City, California, United States
University of Colorado Denver
Aurora, Colorado, United States
Connecticut Children'S Medical Center
Hartford, Connecticut, United States
Nemours Children'S Hospital, Delaware
Wilmington, Delaware, United States
Nemours Children'S Health, Jacksonville
Jacksonville, Florida, United States
Nemours Children'S Hospital, Florida
Orlando, Florida, United States
Kapi'Olani Medical Center for Women & Children
Honolulu, Hawaii, United States
Unity Point Health - Blank Children'S Hospital
Des Moines, Iowa, United States
the University of Iowa
Iowa City, Iowa, United States
Children'S Hospital
New Orleans, Louisiana, United States
Washington University School of Medicine
St Louis, Missouri, United States
Roswell Park Comprehensive Cancer Center
Buffalo, New York, United States
the Trustees of Columbia University in the City of New York
New York, New York, United States
Vanderbilt University Medical Center
Nashville, Tennessee, United States
Driscoll Children'S Hospital
Corpus Christi, Texas, United States
the University of Texas M. D. Anderson Cancer Center
Houston, Texas, United States
the University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States
Virginia Commonwealth University
Richmond, Virginia, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 2 Aug 2021
Primary completion: 18 Oct 2023
Completion: 25 Oct 2023
Last update posted: 23 Sept 2025
Registered enrollment: 445
Registry id: NCT04614662

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.