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Clinical trialNCT04647526Active, not recruitingPhase 3Interventional

Study Evaluating mCRPC Treatment Using PSMA [Lu-177]-PNT2002 Therapy After Second-line Hormonal Treatment

SponsorPOINT Biopharma, a wholly owned subsidiary of Eli Lilly and CompanyEnrollment455Metastatic Castration-Resistant Prostate Cancer
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to evaluate the efficacy and safety of \[Lu-177\]-PNT2002 in patients with metastatic castration-resistant prostate cancer who have progressed following treatment with androgen receptor axis-targeted therapy (ARAT).

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

54 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada
  • Bc Cancer - Vancouver

    Vancouver, British Columbia, Canada

  • Nova Scotia Health Authority

    Halifax, Nova Scotia, Canada

  • London Health Sciences Center - Victoria Hospital

    London, Ontario, Canada

  • Princess Margaret Cancer Centre

    Toronto, Ontario, Canada

  • Sunnybrook Research Institute, Odette Cancer Center

    Toronto, Ontario, Canada

  • Chum - University Hospital of Montreal

    Montreal, Quebec, Canada

  • Jewish General Hospital

    Montreal, Quebec, Canada

  • Chu of Quebec - Laval University

    Québec, Quebec, Canada

France
  • Center Jean Perrin, Department of Medical Oncology

    Clermont-Ferrand, France

  • Claude Huriez Hospital

    Lille, France

  • Leon Berard Center

    Lyon, France

  • la Timone Hospital, Nuclear Medicine Department

    Marseille, France

  • Montpellier Cancer Institute, Department of Nuclear Medicine

    Montpellier, France

  • Tenon Hospital, Department of Medical Oncology

    Paris, France

Netherlands
  • St. Antonius Hospital

    Nieuwegein, Netherlands

  • Radboud University Medical Center (radboudumc)

    Nijmegen, Netherlands

  • Erasmus University Medical Center Rotterdam

    Rotterdam, Netherlands

Sweden
  • Sahlgrenska University Hospital

    Gothenburg, Sweden

  • Norrlands University Hospital, Department of Radiation Sciences, Oncology

    Umeå, Sweden

United Kingdom
  • Charing Cross Hospital, Department of Medical Oncology

    London, United Kingdom

  • Royal Marsden Nhs Foundation Trust - Institute of Cancer Research

    Sutton, United Kingdom

United States
  • Arizona Institute of Urology (aiu) - Tucson

    Tucson, Arizona, United States

  • Cedars-Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute

    Los Angeles, California, United States

  • University of California Los Angeles, Nuclear Medicine Clinic

    Los Angeles, California, United States

  • Va Greater Los Angeles Healthcare System

    Los Angeles, California, United States

  • Hoag Memorial Hospital Presbyterian

    Newport Beach, California, United States

  • Uc Irvine Chao Family Comprehensive Cancer Center

    Orange, California, United States

  • Stanford Cancer Institute

    Palo Alto, California, United States

  • University of Colorado Hospital

    Aurora, Colorado, United States

  • H. Lee Moffitt Cancer Center & Research Institute

    Tampa, Florida, United States

  • University of Iowa Hospitals and Clinics

    Iowa City, Iowa, United States

  • University of Kentucky Chandler Medical Center

    Lexington, Kentucky, United States

  • Tulane University Medical Center

    New Orleans, Louisiana, United States

  • University of Maryland Greenebaum Cancer Center

    Baltimore, Maryland, United States

  • Chesapeake Urology Associates (cua) P.A.

    Towson, Maryland, United States

  • University of Michigan Hospitals

    Ann Arbor, Michigan, United States

  • Karmanos Cancer Center

    Detroit, Michigan, United States

  • Saint Louis University Hospital

    St Louis, Missouri, United States

  • Va St. Louis Health Care System

    St Louis, Missouri, United States

  • Washington University School of Medicine

    St Louis, Missouri, United States

14 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
25 Feb 2021
Primary completion
1 Nov 2023
Completion
31 Mar 2028
Last update posted
13 Jan 2026
Registered enrollment
455
Registry id
NCT04647526

Cross-registrations

EU-CTR / CTIS (EudraCT)2024-515604-39-00EU-CTR / CTIS (EudraCT)2021-002641-15

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 11 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.