Clinical trialNCT04671667RecruitingPhase 2Interventional

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

SponsorNational Cancer Institute (NCI)Enrollment188Recurrent Head and Neck Squamous Cell CarcinomaRecurrent Hypopharyngeal Squamous Cell CarcinomaRecurrent Laryngeal Squamous Cell CarcinomaRecurrent Oral Cavity Squamous Cell CarcinomaRecurrent Oropharyngeal Squamous Cell Carcinoma

View the registry record on ClinicalTrials.gov

Summary

The registered summary isn't in our current data snapshot. Read it on the ClinicalTrials.gov record ↗. Why? →

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Dan P Zandberg
ECOG-ACRIN Cancer Research Group
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

178 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, United States
Active, not recruiting
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
Omar T. Atiq
Recruiting
Kaiser Permanente-Anaheim
Anaheim, California, United States
Aakash Batra
Recruiting
Kaiser Permanente-Bellflower
Bellflower, California, United States
Aakash Batra
Recruiting
Uci Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, California, United States
Shirin Attarian
Recruiting
Uc San Diego Moores Cancer Center
La Jolla, California, United States
Active, not recruiting
Kaiser Permanente Los Angeles Medical Center
Los Angeles, California, United States
Aakash Batra
Recruiting
Kaiser Permanente-Ontario
Ontario, California, United States
Aakash Batra
Recruiting
Uc Irvine Health/chao Family Comprehensive Cancer Center
Orange, California, United States
Shirin Attarian
Recruiting
Sutter Cancer Centers Radiation Oncology Services-Roseville
Roseville, California, United States
Active, not recruiting
Sutter Roseville Medical Center
Roseville, California, United States
Active, not recruiting
California Protons Cancer Therapy Center
San Diego, California, United States
Active, not recruiting
Smilow Cancer Center/yale-New Haven Hospital
New Haven, Connecticut, United States
Aarti Bhatia
Recruiting
Yale University
New Haven, Connecticut, United States
Aarti Bhatia
Recruiting
Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut, United States
Aarti Bhatia
Recruiting
Smilow Cancer Hospital Care Center - Waterford
Waterford, Connecticut, United States
Aarti Bhatia
Recruiting
Medstar Washington Hospital Center
Washington D.C., District of Columbia, United States
Cristina Merkhofer
Recruiting
Um Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, Florida, United States
Elizabeth A. Nicolli
Recruiting
Um Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida, United States
Elizabeth A. Nicolli
Recruiting
Uf Health Cancer Institute - Gainesville
Gainesville, Florida, United States
Active, not recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, United States
Elizabeth A. Nicolli
Recruiting
Um Sylvester Comprehensive Cancer Center at Plantation
Plantation, Florida, United States
Elizabeth A. Nicolli
Recruiting
Moffitt Cancer Center
Tampa, Florida, United States
Kedar Kirtane
Recruiting
Moffitt Cancer Center - Mckinley Campus
Tampa, Florida, United States
Kedar Kirtane
Recruiting
Moffitt Cancer Center-International Plaza
Tampa, Florida, United States
Kedar Kirtane
Recruiting
Moffitt Cancer Center at Wesley Chapel
Wesley Chapel, Florida, United States
Kedar Kirtane
Recruiting
Emory Proton Therapy Center
Atlanta, Georgia, United States
James E. Bates
Recruiting
Emory University Hospital Midtown
Atlanta, Georgia, United States
James E. Bates
Recruiting
Emory University Hospital/winship Cancer Institute
Atlanta, Georgia, United States
Suspended
Memorial Health University Medical Center
Savannah, Georgia, United States
Suspended
John H Stroger Jr Hospital of Cook County
Chicago, Illinois, United States
Deimante M. Tamkus
Recruiting
Northwestern University
Chicago, Illinois, United States
Jochen H. Lorch
Recruiting
University of Illinois
Chicago, Illinois, United States
Ameen Salahudeen
Recruiting
Carle at the Riverfront
Danville, Illinois, United States
Tanmay Sahai
Recruiting
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois, United States
Jochen H. Lorch
Recruiting
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois, United States
Suspended
Decatur Memorial Hospital
Decatur, Illinois, United States
Bryan A. Faller
Recruiting
Carle Physician Group-Effingham
Effingham, Illinois, United States
Tanmay Sahai
Recruiting
Crossroads Cancer Center
Effingham, Illinois, United States
Bryan A. Faller
Recruiting
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois, United States
Jochen H. Lorch
Recruiting

138 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study — it may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 27 Apr 2021
Primary completion: 30 Jun 2029
Completion: 30 Jun 2029
Last update posted: 2 Jul 2026
Registered enrollment: 188
Registry id: NCT04671667

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 12 Jul 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.