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Clinical trialNCT04674683Active, not recruitingPhase 3Interventional

Study Comparing Investigational Drug HBI-8000 + Nivolumab vs. Placebo + Nivolumab in Patients With Advanced Melanoma

SponsorHUYABIO International, LLC.Enrollment450Progressive Brain MetastasisUnresectable or Metastatic Melanoma
View the registry record on ClinicalTrials.gov

Summary

The registered summary isn't in our current data snapshot. Read it on the ClinicalTrials.gov record ↗. Why? →

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

139 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia
  • Sydney Adventist Hospital

    Wahroonga, New South Wales, Australia

  • University of the Sunshine Coast

    Buderim, Queensland, Australia

  • Icon Cancer Centre Wesley

    South Brisbane, Queensland, Australia

  • Ballarat Health Services

    Ballarat, Victoria, Australia

  • Goulburn Valley Health

    Shepparton, Victoria, Australia

  • Royal Brisband and Women'S Hospital

    Brisbane, Australia

  • Liverpool Hospital

    Liverpool, Australia

  • Affinity Clinical Research

    Nedlands, Australia

  • Tweed Hospital

    Tweed Heads, Australia

  • Calvary Mater Newcastle

    Waratah, Australia

Austria
  • Medical University of Graz Department of Dermatology and Venerology

    Graz, Austria

  • Univ.-Lkinik Für Dermatologie, Venerologie Und Allergologie

    Innsbruck, Austria

Belgium
  • Az Klina

    Brasschaat, Belgium

  • Cliniques Universitaires

    Brussels, Belgium

  • Az Maria Middelares

    Ghent, Belgium

  • Jessa Ziekenhuis

    Hasselt, Belgium

  • Hospital de la Citadelle

    Liège, Belgium

  • Clinique Saint-Pierre

    Ottignies, Belgium

Brazil
  • Ensino E Terapia de Inovação Clίnica Amo-Etica

    Salvador, Estado de Bahia, Brazil

  • Hospital Erasto Gaertner - Liga Paranaense de Combate Ao Câncer,

    Curitiba, Paraná, Brazil

  • Hospital Do Câncer de Londrina

    Londrina, Paraná, Brazil

  • Hospital São Vicente de Paulo

    Centro, Rio Grande do Sul, Brazil

  • Hospital Bruno Born

    Lajeado, Rio Grande do Sul, Brazil

  • Centro Gaúcho Integrado de Oncologia, Hematologia

    Porto Alegre, Rio Grande do Sul, Brazil

  • Hospital de Clίnίcas de Porto Alegre

    Santa Cruz do Sul, Rio Grande do Sul, Brazil

  • Oncosite-Centro de Pesquisa Clίnica Em Oncologia

    São Cristóvão, Rio Grande do Sul, Brazil

  • Hopital de Câncer de Barretos-Fundação Pio Xii

    Barretos, São Paulo, Brazil

  • Fundação Doutor Amaral Carvalho

    Jaú, São Paulo, Brazil

  • Cepho-Centro de Estudos E Pesquisas de Hematologia E Oncologia

    Santo André, São Paulo, Brazil

  • Fundação Faculdade Regional de Medicina de São José Do Rio Preto

    São José do Rio Preto, São Paulo, Brazil

  • Instituto Do Cancer Do Estado de São Paulo - "octavio Frias de Oliveira"-Icesp

    São Paulo, São Paulo, Brazil

Czechia
  • Fakultni Nemocnice Olomoue

    Olomouc, Czechia

  • Fakultni Nemocnice Ostrava Kozni Oddeleni

    Ostrava-Poruba, Czechia

  • Fakultni Nemocnice Kralovske Vinohrady

    Prague, Czechia

France
  • Chu de Besançon - Hôpital Jean Minjoz

    Besançon, France

  • Hôpital Ambroise Paré

    Boulogne-Billancourt, France

  • Chu de Dijon, Service de Dermatologie

    Dijon, France

  • Chu Grenoble Alpes

    La Tronche, France

  • Chru Lille - Hôpital Claude Huriez, Clinique de Dermatologie

    Lille, France

  • Hôpital la Timone

    Marseille, France

99 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study — it may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
12 Aug 2021
Primary completion
31 Jul 2026
Completion
31 Dec 2026
Last update posted
24 Sept 2025
Registered enrollment
450
Registry id
NCT04674683

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 12 Jul 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.