Clinical trialNCT04686279CompletedPhase 1Interventional

Tenofovir Rectal Douche to Prevent HIV Transmission Among Adolescents (ATN DREAM)

SponsorUniversity of PennsylvaniaEnrollment8HIV PreventionHIV/AIDS

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

ATN DREAM is an early phase-1, open label study to examine the safety, pharmacokinetics (PK), pharmacodynamics (PD), and acceptability of a one-dose tenofovir (TFV) medicated douche. The overall goal is to inform the design of an extended safety study of an on-demand and behaviorally congruent TFV douche to confer protection from HIV acquisition in an outpatient pre-RAI context

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Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Allison L Agwu, MD
Johns Hopkins University
Study Director
clinicaltrials.gov ↗
Craig W Hendrix, MD
Johns Hopkins University
Principal Investigator
clinicaltrials.gov ↗
Renata Arrington-Sanders, MD
Johns Hopkins University
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

3 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Emory University
Atlanta, Georgia, United States
Johns Hopkins University
Baltimore, Maryland, United States
University of North Carolina - Chapel Hill
Chapel Hill, North Carolina, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Tenofovir Douche

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 1 Apr 2021
Primary completion: 30 Nov 2022
Completion: 30 Nov 2022
Last update posted: 30 Oct 2023
Registered enrollment: 8
Registry id: NCT04686279

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.