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Clinical trialNCT04691622RecruitingPhase 1Interventional

Adoptive T Lymphocyte Administration for Chronic Norovirus Treatment in Immunocompromised Hosts

SponsorChildren's National Research InstituteEnrollment48Hematopoietic Stem Cell Transplantation (HSCT)Primary Immunodeficiency Disorders (PID)Viral Infection
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is a Phase I dose-escalation study to evaluate the safety of norovirus -specific T-cell (NST) therapy for chronic norovirus infection in participants following hematopoietic stem cell transplantation (HSCT) or who are immunocompromised due to PID and have not undergone HSCT, or Solid Organ Transplant (SOT) recipients.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

3 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Children'S National Hospital

    Washington D.C., District of Columbia, United States

    Michael Keller, MD
    Recruiting
  • Johns Hopkins University

    Baltimore, Maryland, United States

    Robin Avery, MD
    Recruiting
  • National Institutes of Health (nih)

    Bethesda, Maryland, United States

    Alison Han, MD
    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Norovirus -specific T-cell therapy
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
17 Mar 2022
Primary completion
30 Aug 2028
Completion
30 Oct 2028
Last update posted
26 Jan 2026
Registered enrollment
48
Registry id
NCT04691622
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.