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Clinical trialNCT04702958CompletedObservational

TRANSFORM-HF Ancillary Mechanistic Study

SponsorInova Health Care ServicesEnrollment150Heart Failure
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Patients with heart failure are frequently treated with diuretics, including furosemide and torsemide, but it is not known if one is better than the other. The TRANSFORM-HF trial is studying if torsemide is superior than furosemide for reducing the endpoint of death or hospitalization, but is not designed to study why. This ancillary study seeks to measure proteins in the blood and urine to help explain the underlying mechanism for why patients who take one of these diuretics may have better outcomes than patients who take the other.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

9 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Yale University School of Medicine

    New Haven, Connecticut, United States

  • Ochsner Clinic Foundation

    New Orleans, Louisiana, United States

  • Baltimore Va

    Baltimore, Maryland, United States

  • University of Minnesota

    Minneapolis, Minnesota, United States

  • Northwell Health

    Manhasset, New York, United States

  • University of North Carolina at Chapel Hill

    Chapel Hill, North Carolina, United States

  • Duke University Hospital

    Durham, North Carolina, United States

  • Inova Health System

    Falls Church, Virginia, United States

  • Sentara Norfolk

    Norfolk, Virginia, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
10 Dec 2020
Primary completion
30 May 2023
Completion
30 May 2023
Last update posted
10 Oct 2023
Registered enrollment
150
Registry id
NCT04702958
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.