Clinical trialNCT04709562CompletedInterventional

Clinical Stabilization of Hypercapnia: NIPPV v HVNI

SponsorVapotherm, Inc.Enrollment68Chronic Obstructive Pulmonary DiseaseDyspneaHypercapnic AcidosisHypercapnic Respiratory Failure

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This study will evaluate the ability of High Velocity Nasal Insufflation \[HVNI\] to effect ventilation and related physiologic responses in hypercapnic patients when compared to noninvasive positive pressure ventilation \[NIPPV\].

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Andrew Meltzer, MD, MS
George Washington University
Principal Investigator
clinicaltrials.gov ↗
Anthony Innabi, MBA, RRT-NPS
Dignity Health Medical Foundation
Principal Investigator
clinicaltrials.gov ↗
Christopher W Jones, MD
The Cooper Health System
Principal Investigator
clinicaltrials.gov ↗
Cynthia Pfeiffer, MD
Valley Presbyterian Hospital
Principal Investigator
clinicaltrials.gov ↗
David Yamane, MD
George Washington University
Principal Investigator
clinicaltrials.gov ↗
Joshua Oliver, MD
Madigan Army Medical Hospital
Principal Investigator
clinicaltrials.gov ↗
Richard Wilkerson, MD
University of Maryland
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

7 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Valley Presbyterian Hospital
Los Angeles, California, United States
Dignity Health - St. John'S Regional Medical Center
Oxnard, California, United States
George Washington University Hospital
Washington D.C., District of Columbia, United States
University of Maryland
Baltimore, Maryland, United States
Cooper University Hospital
Camden, New Jersey, United States
Erlanger Health System
Chattanooga, Tennessee, United States
Madigan Army Medical Center
Tacoma, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 11 Nov 2020
Primary completion: 26 May 2023
Completion: 22 Jun 2023
Last update posted: 9 Aug 2024
Registered enrollment: 68
Registry id: NCT04709562

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.