Clinical trialNCT04732091UnknownObservational

Therapeutic Use of Contrast Ultrasound in Acute Coronary Artery Disease

SponsorUniversity of Sao Paulo General HospitalEnrollment540Acute Myocardial InfarctionUnstable Angina

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Preclinical studies have demonstrated that high mechanical index (MI) impulses from a diagnostic ultrasound (DUS) transducer during an intravenous microbubble infusion (sonothrombolysis) can restore epicardial and microvascular flow in acute ST-segment elevation myocardial infarction (STEMI). The investigators propose to demonstrate the clinical effectiveness of sonothrombolysis in multiple centers and in a wide scenario of acute coronary syndromes.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Jeane Tsutsui, MD, PhD
Heart Institute - University of São Paulo Medical School
Principal Investigator
clinicaltrials.gov ↗
Thomas R Porter, MD
University of Nebraska Medical Center, Omaha, NE
Principal Investigator
clinicaltrials.gov ↗
Wilson Mathias Jr, MD, PhD
Heart Institute - University of São Paulo Medical School
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

2 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Brazil

Heart Institute of Clinical Hospital of Medical School of University of Sao Paulo
São Paulo, Brazil
Recruiting

United States

Department of Internal Medicine, Division of Cardiovascular Medicine, University of Nebraska Medical Center
Omaha, Nebraska, United States
Active, not recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 17 Feb 2022
Primary completion: 1 Feb 2024
Completion: 1 Feb 2026
Last update posted: 10 Oct 2023
Registered enrollment: 540
Registry id: NCT04732091

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.