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Clinical trialNCT04751370Active, not recruitingPhase 2Interventional

Testing Nivolumab and Ipilimumab With Short-Course Radiation in Locally Advanced Rectal Cancer

SponsorNational Cancer Institute (NCI)Enrollment31Locally Advanced Rectal AdenocarcinomaStage II Rectal Cancer AJCC v8Stage III Rectal Cancer AJCC v8
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase II trial investigates the effect of nivolumab and ipilimumab when given together with short-course radiation therapy in treating patients with rectal cancer that has spread to nearby tissue or lymph nodes (locally advanced). Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Giving nivolumab, ipilimumab, and radiation therapy may kill more cancer cells.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

213 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Mobile Infirmary Medical Center

    Mobile, Alabama, United States

  • Alaska Breast Care and Surgery Llc

    Anchorage, Alaska, United States

  • Alaska Oncology and Hematology Llc

    Anchorage, Alaska, United States

  • Alaska Women'S Cancer Care

    Anchorage, Alaska, United States

  • Anchorage Associates in Radiation Medicine

    Anchorage, Alaska, United States

  • Anchorage Oncology Centre

    Anchorage, Alaska, United States

  • Katmai Oncology Group

    Anchorage, Alaska, United States

  • Providence Alaska Medical Center

    Anchorage, Alaska, United States

  • Cancer Center at Saint Joseph'S

    Phoenix, Arizona, United States

  • Mercy Hospital Fort Smith

    Fort Smith, Arkansas, United States

  • Chi Saint Vincent Cancer Center Hot Springs

    Hot Springs, Arkansas, United States

  • Pcr Oncology

    Arroyo Grande, California, United States

  • Providence Saint Joseph Medical Center/disney Family Cancer Center

    Burbank, California, United States

  • Usc / Norris Comprehensive Cancer Center

    Los Angeles, California, United States

  • Uc Irvine Health/chao Family Comprehensive Cancer Center

    Orange, California, United States

  • Pacific Central Coast Health Center-San Luis Obispo

    San Luis Obispo, California, United States

  • Mission Hope Medical Oncology - Santa Maria

    Santa Maria, California, United States

  • Penrose-Saint Francis Healthcare

    Colorado Springs, Colorado, United States

  • Rocky Mountain Cancer Centers-Penrose

    Colorado Springs, Colorado, United States

  • Adventhealth Porter

    Denver, Colorado, United States

  • Commonspirit Saint Anthony Hospital Cancer Center

    Lakewood, Colorado, United States

  • Adventhealth Littleton

    Littleton, Colorado, United States

  • Longmont United Hospital

    Longmont, Colorado, United States

  • Adventhealth Parker

    Parker, Colorado, United States

  • Saint Mary Corwin Medical Center

    Pueblo, Colorado, United States

  • Beebe South Coastal Health Campus

    Millville, Delaware, United States

  • Helen F Graham Cancer Center

    Newark, Delaware, United States

  • Medical Oncology Hematology Consultants Pa

    Newark, Delaware, United States

  • Beebe Health Campus

    Rehoboth Beach, Delaware, United States

  • Adventhealth Altamonte

    Altamonte Springs, Florida, United States

  • Adventhealth Orlando

    Orlando, Florida, United States

  • Saint Alphonsus Cancer Care Center-Boise

    Boise, Idaho, United States

  • Saint Luke'S Cancer Institute - Boise

    Boise, Idaho, United States

  • Saint Alphonsus Cancer Care Center-Caldwell

    Caldwell, Idaho, United States

  • Kootenai Health - Coeur D'Alene

    Coeur d'Alene, Idaho, United States

  • Saint Luke'S Cancer Institute - Fruitland

    Fruitland, Idaho, United States

  • Idaho Urologic Institute-Meridian

    Meridian, Idaho, United States

  • Saint Luke'S Cancer Institute - Meridian

    Meridian, Idaho, United States

  • Saint Alphonsus Cancer Care Center-Nampa

    Nampa, Idaho, United States

  • Saint Luke'S Cancer Institute - Nampa

    Nampa, Idaho, United States

173 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Ipilimumab →Nivolumab →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
8 Feb 2022
Primary completion
31 Dec 2026
Completion
31 Dec 2026
Last update posted
4 Aug 2026
Registered enrollment
31
Registry id
NCT04751370
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.