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Clinical trialNCT04754945Active, not recruitingPhase 1Interventional

Isatuximab as Upfront Therapy for the Treatment of High Risk AL Amyloidosis

SponsorEmory UniversityEnrollment11AL Amyloidosis
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase I trial studies the side effects of isatuximab and to see how well it works in treating patients with high risk immunoglobulin light chain amyloidosis (AL amyloidosis). Isatuximab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

6 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • University of California

    Orange, California, United States

  • Emory University Hospital Midtown

    Atlanta, Georgia, United States

  • Emory University Hospital/winship Cancer Institute

    Atlanta, Georgia, United States

  • Karmanos Cancer Institute

    Detroit, Michigan, United States

  • Columbia University

    New York, New York, United States

  • Ut Southwestern

    Dallas, Texas, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Bortezomib →Cyclophosphamide →Dexamethasone →Isatuximab →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
28 Apr 2021
Primary completion
6 May 2027
Completion
24 Jul 2028
Last update posted
14 Jul 2026
Registered enrollment
11
Registry id
NCT04754945
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.