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Clinical trialNCT04797286RecruitingPhase 2Interventional

Sildenafil for Early Pulmonary Vascular Disease in Scleroderma

SponsorJohns Hopkins UniversityEnrollment30Mildly Elevated Pulmonary PressuresScleroderma
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is a Phase II randomized, double-blind, placebo-controlled trial of sildenafil in men and women with Scleroderma with mildly elevated pulmonary pressures (SSc-MEP) to determine whether sildenafil may be an effective treatment for SSc-MEP.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

2 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Louisiana State University

    New Orleans, Louisiana, United States

    Matthew Lammi, MD
    Not, yet, recruiting
  • Johns Hopkins

    Baltimore, Maryland, United States

    Stephen Mathai, MD →
    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Sildenafil →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
20 Sept 2021
Primary completion
1 Sept 2026
Completion
1 Sept 2026
Last update posted
15 Oct 2025
Registered enrollment
30
Registry id
NCT04797286
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.