Clinical trialNCT04804644RecruitingPhase 3Interventional

Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability

SponsorNRG OncologyEnrollment200Metastatic Lung Small Cell CarcinomaMetastatic Malignant Neoplasm in the BrainRecurrent Lung Small Cell CarcinomaStage IV Lung Cancer AJCC v8

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase III trial compares the effect of stereotactic radiosurgery to standard of care memantine and whole brain radiation therapy that avoids the hippocampus (the memory zone of the brain) for the treatment of small cell lung cancer that has spread to the brain. Stereotactic radiosurgery is a specialized radiation therapy that delivers a single, high dose of radiation directly to the tumor and may cause less damage to normal tissue. Whole brain radiation therapy delivers a low dose of radiation to the entire brain including the normal brain tissue. Hippocampal avoidance during whole-brain radiation therapy (HA-WBRT) decreases the amount of radiation that is delivered to the hippocampus which is a brain structure that is important for memory. The drug, memantine, is also often given with whole brain radiotherapy because it may decrease the risk of side effects related to thinking and memory. Stereotactic radiosurgery may decrease side effects related to memory and thinking compared to standard of care HA-WBRT plus memantine.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Vinai Gondi
NRG Oncology
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

231 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

University Health Network-Princess Margaret Hospital
Toronto, Ontario, Canada
Suspended
Chu de Quebec-L'Hotel-Dieu de Quebec (hdq)
Québec, Quebec, Canada
Isabelle Thibault
Recruiting
Allan Blair Cancer Centre
Regina, Saskatchewan, Canada
Taskia Mir
Recruiting
Saskatoon Cancer Centre
Saskatoon, Saskatchewan, Canada
Vijayananda Kundapur
Recruiting

United States

Mayo Clinic Hospital in Arizona
Phoenix, Arizona, United States
Active, not recruiting
Kaiser Permanente-Anaheim
Anaheim, California, United States
Aakash Batra
Recruiting
Kaiser Permanente-Bellflower
Bellflower, California, United States
Aakash Batra
Recruiting
Kaiser Permanente Los Angeles Medical Center
Los Angeles, California, United States
Aakash Batra
Recruiting
Los Angeles General Medical Center
Los Angeles, California, United States
Jason C. Ye
Recruiting
Usc / Norris Comprehensive Cancer Center
Los Angeles, California, United States
Jason C. Ye
Recruiting
Kaiser Permanente-Ontario
Ontario, California, United States
Aakash Batra
Recruiting
Uchealth University of Colorado Hospital
Aurora, Colorado, United States
Active, not recruiting
Memorial Hospital North
Colorado Springs, Colorado, United States
Active, not recruiting
Uchealth Memorial Hospital Central
Colorado Springs, Colorado, United States
Active, not recruiting
Smilow Cancer Hospital Care Center at Greenwich
Greenwich, Connecticut, United States
Terminated
Smilow Cancer Hospital Care Center - Guilford
Guilford, Connecticut, United States
Terminated
Smilow Cancer Center/yale-New Haven Hospital
New Haven, Connecticut, United States
Terminated
Yale University
New Haven, Connecticut, United States
Terminated
Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut, United States
Terminated
Smilow Cancer Hospital Care Center - Waterford
Waterford, Connecticut, United States
Terminated
Beebe Medical Center
Lewes, Delaware, United States
Active, not recruiting
Christiana Care Health System-Christiana Hospital
Newark, Delaware, United States
Active, not recruiting
Delaware Clinical and Laboratory Physicians Pa
Newark, Delaware, United States
Active, not recruiting
Helen F Graham Cancer Center
Newark, Delaware, United States
Active, not recruiting
Medical Oncology Hematology Consultants Pa
Newark, Delaware, United States
Active, not recruiting
Beebe Health Campus
Rehoboth Beach, Delaware, United States
Active, not recruiting
Christiana Care Health System-Wilmington Hospital
Wilmington, Delaware, United States
Active, not recruiting
Um Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, Florida, United States
Active, not recruiting
Um Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida, United States
Active, not recruiting
Uf Health Cancer Institute - Gainesville
Gainesville, Florida, United States
Active, not recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, United States
Active, not recruiting
Moffitt Cancer Center
Tampa, Florida, United States
Hsiang-Hsuan M. Yu
Recruiting
Moffitt Cancer Center - Mckinley Campus
Tampa, Florida, United States
Hsiang-Hsuan M. Yu
Recruiting
Moffitt Cancer Center-International Plaza
Tampa, Florida, United States
Hsiang-Hsuan M. Yu
Recruiting
Moffitt Cancer Center at Wesley Chapel
Wesley Chapel, Florida, United States
Hsiang-Hsuan M. Yu
Recruiting
Emory Saint Joseph'S Hospital
Atlanta, Georgia, United States
Active, not recruiting
Emory University Hospital Midtown
Atlanta, Georgia, United States
Active, not recruiting
Emory University Hospital/winship Cancer Institute
Atlanta, Georgia, United States
Active, not recruiting
Northside Hospital
Atlanta, Georgia, United States
Gena H. Volas-Redd
Recruiting
Northside Hospital-Cherokee
Canton, Georgia, United States
Gena H. Volas-Redd
Recruiting

191 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Memantine →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 8 Jun 2021
Primary completion: 24 Jun 2026
Completion: 1 Jul 2031
Last update posted: 17 Aug 2026
Registered enrollment: 200
Registry id: NCT04804644

Cross-registrations

Other registry (CTRP (Clinical Trial Reporting ProgramNCI-2020-11651

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.