Clinical trialNCT04840602RecruitingPhase 2Interventional

Testing the Combination of Venetoclax and Rituximab, in Comparison to the Usual Treatment (Ibrutinib Plus Rituximab or Zanubrutinib Alone) for Waldenstrom's Macroglobulinemia/Lymphoplasmacytic Lymphoma

SponsorNational Cancer Institute (NCI)Enrollment92Lymphoplasmacytic LymphomaWaldenstrom Macroglobulinemia

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase II trial studies the effects of venetoclax and rituximab in comparison to ibrutinib and rituximab or zanubrutinib in treating patients with previously untreated Waldenstrom's macroglobulinemia/lymphoplasmacytic lymphoma. Ibrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Rituximab is a monoclonal antibody. It binds to a protein called CD20, which is found on B cells (a type of white blood cell) and some types of cancer cells. This may help the immune system kill cancer cells. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Zanubrutinib, a type of tyrosine kinase inhibitor, blocks a protein called BTK, which may help keep cancer cells from growing. Giving venetoclax and rituximab may work better in treating patients with previously untreated Waldenstrom's macroglobulinemia than ibrutinib with rituximab or zanubrutinib alone.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Sikander Ailawadhi
SWOG Cancer Research Network
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

138 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Banner University Medical Center - Tucson
Tucson, Arizona, United States
Muhammad Husnain
Recruiting
University of Arizona Cancer Center-North Campus
Tucson, Arizona, United States
Muhammad Husnain
Recruiting
City of Hope at Irvine Lennar
Irvine, California, United States
Benjamin M. Heyman
Recruiting
Um Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, Florida, United States
Georgios Pongas
Recruiting
Um Sylvester Comprehensive Cancer Center at Coral Springs
Coral Springs, Florida, United States
Georgios Pongas
Recruiting
Um Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida, United States
Georgios Pongas
Recruiting
Um Sylvester Comprehensive Cancer Center at Doral
Doral, Florida, United States
Georgios Pongas
Recruiting
Um Sylvester Comprehensive Cancer Center at Hollywood
Hollywood, Florida, United States
Georgios Pongas
Recruiting
Mayo Clinic in Florida
Jacksonville, Florida, United States
Sikander Ailawadhi →
Recruiting
Um Sylvester Comprehensive Cancer Center at Kendall
Miami, Florida, United States
Georgios Pongas
Recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, United States
Georgios Pongas
Recruiting
University of Miami Sylvester Comprehensive Cancer Center at Sole Mia
North Miami, Florida, United States
Georgios Pongas
Recruiting
Um Sylvester Comprehensive Cancer Center at Plantation
Plantation, Florida, United States
Georgios Pongas
Recruiting
Saint Alphonsus Cancer Care Center-Nampa
Nampa, Idaho, United States
Tareq Al baghdadi
Recruiting
Centralia Oncology Clinic
Centralia, Illinois, United States
Bryan A. Faller
Recruiting
Carle at the Riverfront
Danville, Illinois, United States
Priyank P. Patel
Recruiting
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois, United States
Bryan A. Faller
Recruiting
Carle Physician Group-Effingham
Effingham, Illinois, United States
Priyank P. Patel
Recruiting
Crossroads Cancer Center
Effingham, Illinois, United States
Bryan A. Faller
Recruiting
Carle Physician Group-Mattoon/charleston
Mattoon, Illinois, United States
Priyank P. Patel
Recruiting
Loyola University Medical Center
Maywood, Illinois, United States
Patrick A. Hagen
Recruiting
Cancer Care Center of O'Fallon
O'Fallon, Illinois, United States
Bryan A. Faller
Recruiting
Southern Illinois University School of Medicine
Springfield, Illinois, United States
Bryan A. Faller
Recruiting
Springfield Clinic
Springfield, Illinois, United States
Bryan A. Faller
Recruiting
Springfield Memorial Hospital
Springfield, Illinois, United States
Bryan A. Faller
Recruiting
Carle Cancer Center
Urbana, Illinois, United States
Priyank P. Patel
Recruiting
Mary Greeley Medical Center
Ames, Iowa, United States
Joseph J. Merchant
Recruiting
Mcfarland Clinic - Ames
Ames, Iowa, United States
Joseph J. Merchant
Recruiting
Mcfarland Clinic - Boone
Boone, Iowa, United States
Suspended
Mcfarland Clinic - Trinity Cancer Center
Fort Dodge, Iowa, United States
Joseph J. Merchant
Recruiting
Mcfarland Clinic - Jefferson
Jefferson, Iowa, United States
Suspended
Mcfarland Clinic - Marshalltown
Marshalltown, Iowa, United States
Joseph J. Merchant
Recruiting
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan, United States
Tareq Al baghdadi
Recruiting
Trinity Health Iha Medical Group Hematology Oncology - Brighton
Brighton, Michigan, United States
Tareq Al baghdadi
Recruiting
Trinity Health Medical Center - Brighton
Brighton, Michigan, United States
Tareq Al baghdadi
Recruiting
Trinity Health Iha Medical Group Hematology Oncology - Canton
Canton, Michigan, United States
Tareq Al baghdadi
Recruiting
Trinity Health Medical Center - Canton
Canton, Michigan, United States
Tareq Al baghdadi
Recruiting
Chelsea Hospital
Chelsea, Michigan, United States
Tareq Al baghdadi
Recruiting
Trinity Health Iha Medical Group Hematology Oncology - Chelsea Hospital
Chelsea, Michigan, United States
Tareq Al baghdadi
Recruiting
Hematology Oncology Consultants-Clarkston
Clarkston, Michigan, United States
Tareq Al baghdadi
Recruiting

98 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Ibrutinib →Rituximab →Venetoclax →Zanubrutinib →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 5 Jan 2022
Primary completion: 31 Mar 2028
Completion: 31 Mar 2028
Last update posted: 29 Jul 2026
Registered enrollment: 92
Registry id: NCT04840602

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.