Clinical trialNCT04870944RecruitingPhase 1/PHASE2Interventional

CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma

SponsorChildren's Oncology GroupEnrollment63Diffuse Midline Glioma, H3 K27-AlteredMetastatic Malignant Neoplasm in the Central Nervous SystemRecurrent Diffuse Intrinsic Pontine GliomaRecurrent Diffuse Midline Glioma, H3 K27-AlteredRecurrent LymphomaRecurrent Malignant Solid Neoplasm+4 more conditions

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase I/II trial evaluates the best dose, side effects and possible benefit of CBL0137 in treating patients with solid tumors, including central nervous system (CNS) tumors or lymphoma that has come back (relapsed) or does not respond to treatment (refractory). Drugs, such as CBL0137, block signals passed from one molecule to another inside a cell. Blocking these signals can affect many functions of the cell, including cell division and cell death, and may kill cancer cells.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

David S Ziegler
Pediatric Early Phase Clinical Trial Network
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

35 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia

Sydney Children'S Hospital
Randwick, New South Wales, Australia
Suspended

United States

Children'S Hospital of Alabama
Birmingham, Alabama, United States
Girish Dhall
Recruiting
Phoenix Childrens Hospital
Phoenix, Arizona, United States
Alok K. Kothari
Recruiting
Children'S Hospital Los Angeles
Los Angeles, California, United States
Fariba Navid
Recruiting
Children'S Hospital of Orange County
Orange, California, United States
Josephine H. Haduong
Recruiting
Ucsf Medical Center-Mission Bay
San Francisco, California, United States
Kieuhoa T. Vo
Recruiting
Children'S Hospital Colorado
Aurora, Colorado, United States
Margaret E. Macy
Recruiting
Children'S National Medical Center
Washington D.C., District of Columbia, United States
AeRang Kim
Recruiting
Johns Hopkins All Children'S Hospital
St. Petersburg, Florida, United States
Jonathan L. Metts
Recruiting
Children'S Healthcare of Atlanta - Arthur M Blank Hospital
Atlanta, Georgia, United States
Jason R. Fangusaro
Recruiting
Lurie Children'S Hospital-Chicago
Chicago, Illinois, United States
Elizabeth A. Sokol
Recruiting
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, United States
Ami V. Desai
Recruiting
Riley Hospital for Children
Indianapolis, Indiana, United States
Brian D. Weiss
Recruiting
Johns Hopkins University/sidney Kimmel Cancer Center
Baltimore, Maryland, United States
Christine A. Pratilas
Recruiting
Dana-Farber Cancer Institute
Boston, Massachusetts, United States
Steven G. DuBois →
Recruiting
C S Mott Children'S Hospital
Ann Arbor, Michigan, United States
Rajen Mody
Recruiting
University of Minnesota/masonic Cancer Center
Minneapolis, Minnesota, United States
Robin L. Williams
Recruiting
Children'S Mercy Hospitals and Clinics
Kansas City, Missouri, United States
Kevin F. Ginn
Recruiting
Washington University School of Medicine
St Louis, Missouri, United States
Shalini Shenoy
Recruiting
Roswell Park Cancer Institute
Buffalo, New York, United States
Clare J. Twist
Recruiting
Memorial Sloan Kettering Cancer Center
New York, New York, United States
Julia L. Glade Bender
Recruiting
Nyp/columbia University Medical Center/herbert Irving Comprehensive Cancer Center
New York, New York, United States
Nobuko Hijiya
Recruiting
New York Medical College
Valhalla, New York, United States
Mitchell S. Cairo →
Recruiting
Duke University Medical Center
Durham, North Carolina, United States
Jessica M. Sun
Recruiting
Cincinnati Children'S Hospital Medical Center
Cincinnati, Ohio, United States
Joseph G. Pressey
Recruiting
Oregon Health and Science University
Portland, Oregon, United States
Bill H. Chang
Recruiting
Children'S Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
Theodore W. Laetsch
Recruiting
Children'S Hospital of Pittsburgh of Upmc
Pittsburgh, Pennsylvania, United States
Andrew Bukowinski
Recruiting
Saint Jude Children'S Research Hospital
Memphis, Tennessee, United States
Dana Tlais
Recruiting
Ut Southwestern/simmons Cancer Center-Dallas
Dallas, Texas, United States
Laura J. Klesse
Recruiting
Cook Children'S Medical Center
Fort Worth, Texas, United States
Sibo Zhao
Recruiting
Baylor College of Medicine/dan L Duncan Comprehensive Cancer Center
Houston, Texas, United States
Jennifer H. Foster
Recruiting
Primary Children'S Hospital
Salt Lake City, Utah, United States
Matthew Dietz
Recruiting
Seattle Children'S Hospital
Seattle, Washington, United States
Katherine G. Tarlock
Recruiting
Children'S Hospital of Wisconsin
Milwaukee, Wisconsin, United States
Sarah Rumler
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

FACT Complex-targeting Curaxin CBL0137

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 28 Jan 2022
Primary completion: 31 Dec 2026
Completion: 31 Dec 2026
Last update posted: 5 May 2026
Registered enrollment: 63
Registry id: NCT04870944

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.