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Clinical trialNCT04883411RecruitingInterventional

CEM-Plate and CEM-Cage First-In-Human Use Efficacy Study

SponsorReVivo Medical, Corp.Enrollment50Intervertebral Disc Disorder CervicalNeck PainSpondylosisSpondylosis With MyelopathySpondylosis With RadiculopathySpondylosis With Radiculopathy Cervical Region
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The study is a prospective, first-in-human, multi-center, non-randomized, single-arm study to assess the safety and efficacy of the CEM-Cage used with the CEM-Plate in patients who are appropriate candidates for a 2-level anterior cervical discectomy and fusion (ACDF). Fifty patients will be enrolled in the study and, after undergoing a 2-level ACDF, will be evaluated at 4 weeks, 3 months, 6 months, 12 months, 18 months, and 24 months.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

4 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Igea

    Union, New Jersey, United States

    Adam Lipson, MD
    Recruiting
  • Albany Medical College

    Albany, New York, United States

    Ahmed Meleis, MDAlexander Riccio, MDDarryl DiRisio, MDFrank Genovese, MDJohn Dalfino, MDJohn German, MDRobert Cheney, MD
    Recruiting
  • University at Buffalo Neurosurgery

    Williamsville, New York, United States

    Jeffrey Mullin, MDJohn Pollina, MD
    Recruiting
  • Cleveland Clinic

    Cleveland, Ohio, United States

    Dominic Pelle, MDIain Kalfas, MDMichael Steinmetz, MD
    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study — it may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
7 Mar 2022
Primary completion
31 Aug 2027
Completion
31 Dec 2027
Last update posted
18 Apr 2025
Registered enrollment
50
Registry id
NCT04883411
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.