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Clinical trialNCT04925375RecruitingPhase 2Interventional

Abatacept for the Treatment of Common Variable Immunodeficiency With Interstitial Lung Disease

SponsorChildren's Hospital Medical Center, CincinnatiEnrollment38Common Variable ImmunodeficiencyInterstitial Lung Disease
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

There is no standard of care therapy for patients with granulomatous-lymphocytic interstitial lung disease (GLILD) seen in common variable immunodeficiency (CVID). Abatacept has recently looked promising for the treatment of patients with complex CVID. This study is a multi-site, phase II, randomized, blinded/placebo-controlled clinical trial in pediatric and adult subjects to determine the efficacy of abatacept compared to placebo for treatment of subjects with GLILD in the context of CVID. Funding Source - FDA OOPD
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

6 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • University of California, San Francisco

    San Francisco, California, United States

    Michele Pham, MD
    Recruiting
  • University of South Florida

    Tampa, Florida, United States

    Jolan Walter, MD
    Recruiting
  • Lahey Hospital and Medical Center

    Burlington, Massachusetts, United States

    Jocelyn Farmer, MD
    Recruiting
  • Mayo Clinic

    Rochester, Minnesota, United States

    Avni Joshi, MD
    Recruiting
  • Duke University Health System

    Durham, North Carolina, United States

    Peter Bressler, MD
    Recruiting
  • Cincinnati Children'S Hospital Medical Center

    Cincinnati, Ohio, United States

    Michael Jordan, MD
    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Abatacept →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
14 Jul 2021
Primary completion
31 Jul 2028
Completion
31 Jul 2028
Last update posted
22 Jul 2026
Registered enrollment
38
Registry id
NCT04925375
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.