Clinical trialNCT04936230TerminatedPhase 2Interventional

Immunotherapy With or Without Radiation Therapy for Metastatic Urothelial Cancer

SponsorNational Cancer Institute (NCI)Enrollment1Metastatic Urothelial CarcinomaPlatinum-Resistant Urothelial CarcinomaStage IV Bladder Cancer AJCC v8

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase II trial compares the effect of adding radiation therapy to an immunotherapy drug called pembrolizumab versus pembrolizumab alone in treating patients with urothelial cancer that has spread from where it first started (primary site) to other places in the body (metastatic). The addition of radiation to immunotherapy may shrink the cancer, but it could also cause side effects. Immunotherapy with monoclonal antibodies such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Stereotactic body radiation therapy (SBRT) is a type of radiation therapy that uses high energy x-rays to kill tumor cells and shrink tumors. This method uses special equipment to position a patient and precisely deliver radiation to tumors with high precision. This method may kill tumor cells with fewer doses over a shorter period and may cause less damage to normal tissue than conventional radiation therapy. The combination of pembrolizumab and radiation therapy may be more efficient in killing tumor cells.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Himanshu Nagar
Alliance for Clinical Trials in Oncology
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

83 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Littleton Adventist Hospital
Littleton, Colorado, United States
Illinois Cancercare-Bloomington
Bloomington, Illinois, United States
Illinois Cancercare-Canton
Canton, Illinois, United States
Illinois Cancercare-Carthage
Carthage, Illinois, United States
Centralia Oncology Clinic
Centralia, Illinois, United States
Rush University Medical Center
Chicago, Illinois, United States
University of Illinois
Chicago, Illinois, United States
Carle at the Riverfront
Danville, Illinois, United States
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois, United States
Decatur Memorial Hospital
Decatur, Illinois, United States
Carle Physician Group-Effingham
Effingham, Illinois, United States
Crossroads Cancer Center
Effingham, Illinois, United States
Illinois Cancercare-Eureka
Eureka, Illinois, United States
Illinois Cancercare-Galesburg
Galesburg, Illinois, United States
Illinois Cancercare-Kewanee Clinic
Kewanee, Illinois, United States
Illinois Cancercare-Macomb
Macomb, Illinois, United States
Carle Physician Group-Mattoon/charleston
Mattoon, Illinois, United States
Cancer Care Center of O'Fallon
O'Fallon, Illinois, United States
Hshs Saint Elizabeth'S Hospital
O'Fallon, Illinois, United States
Illinois Cancercare-Ottawa Clinic
Ottawa, Illinois, United States
Illinois Cancercare-Pekin
Pekin, Illinois, United States
Illinois Cancercare-Peoria
Peoria, Illinois, United States
Osf Saint Francis Medical Center
Peoria, Illinois, United States
Illinois Cancercare-Peru
Peru, Illinois, United States
Illinois Cancercare-Princeton
Princeton, Illinois, United States
Southern Illinois University School of Medicine
Springfield, Illinois, United States
Springfield Clinic
Springfield, Illinois, United States
Springfield Memorial Hospital
Springfield, Illinois, United States
Carle Cancer Center
Urbana, Illinois, United States
Illinois Cancercare - Washington
Washington, Illinois, United States
Mission Cancer and Blood - Ankeny
Ankeny, Iowa, United States
Mercy Cancer Center-West Lakes
Clive, Iowa, United States
Greater Regional Medical Center
Creston, Iowa, United States
Broadlawns Medical Center
Des Moines, Iowa, United States
Iowa Methodist Medical Center
Des Moines, Iowa, United States
Mercy Medical Center - Des Moines
Des Moines, Iowa, United States
Mission Cancer and Blood - Des Moines
Des Moines, Iowa, United States
Mercy Medical Center-West Lakes
West Des Moines, Iowa, United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan, United States
Trinity Health Iha Medical Group Hematology Oncology - Brighton
Brighton, Michigan, United States

43 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Pembrolizumab →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 22 Nov 2022
Primary completion: 15 Aug 2024
Completion: 15 Aug 2024
Last update posted: 17 Aug 2025
Registered enrollment: 1
Registry id: NCT04936230

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.