Clinical trialNCT04939935RecruitingPhase 3Interventional

Implementation of Metformin theraPy to Ease Decline of Kidney Function in Polycystic Kidney Disease (IMPEDE-PKD)

SponsorThe University of QueenslandEnrollment1,174Autosomal Dominant Polycystic Kidney Disease

View the registry record on ClinicalTrials.gov

Summary

The registered summary isn't in our current data snapshot. Read it on the ClinicalTrials.gov record ↗. Why? →

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Andrew Mallett, MBBS, PhD
Townsville University Hospital
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

49 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia

Renal Research
Gosford, New South Wales, Australia
Active, not recruiting
Royal North Shore Hospital
Sydney, New South Wales, Australia
Active, not recruiting
Royal Prince Alfred Hospital
Sydney, New South Wales, Australia
Active, not recruiting
Westmead Hospital - Western Sydney Local Health District
Sydney, New South Wales, Australia
Active, not recruiting
Bundaberg Hospital
Bundaberg, Queensland, Australia
Active, not recruiting
Townsville University Hospital
Douglas, Queensland, Australia
Active, not recruiting
Royal Brisbane and Women'S Hospital
Herston, Queensland, Australia
Active, not recruiting
Princess Alexandra Hospital
Woolloongabba, Queensland, Australia
Active, not recruiting
Royal Adelaide Hospital
Adelaide, South Australia, Australia
Active, not recruiting
Austin Health
Melbourne, Victoria, Australia
Active, not recruiting
Monash Medical Centre
Melbourne, Victoria, Australia
Active, not recruiting
Royal Melbourne Hospital
Melbourne, Victoria, Australia
Active, not recruiting
Sir Charles Gairdner Hospital
Perth, Western Australia, Australia
Active, not recruiting

New Zealand

Te Whatu Ora - Hauora A Toi Bay of Plenty
Tauranga, Bay of Plenty, New Zealand
Scott Crawford, Dr
Recruiting
Te Whatu Ora - Te Tai Tokerau
Whangārei, Northland, New Zealand
Adam Mullan, Dr
Recruiting
Te Whatu Ora - Southern
Dunedin, Otago, New Zealand
Rob Walker, Professor
Recruiting
Te Whatu Ora - Taranaki
New Plymouth, Taranaki Region, New Zealand
Mahmoud Amer, Dr
Recruiting
Ta Pae Hauora O Ruhahine O Terarua Mid Central
Palmerston North, New Zealand
Recruiting

United Kingdom

Royal Devon & Exeter Hospital
Exeter, Devon, United Kingdom
Rhian Clissold, Dr
Recruiting
Nottingham Renal Unit, Nottingham City Hospital
Nottingham, East Midlands, United Kingdom
Matt Hall, Dr
Not, yet, recruiting
Raigmore Hospital
Inverness, Inverness Shire, United Kingdom
Stewart Lambie, Dr
Not, yet, recruiting
Royal Preston Hospital
Preston, Lancashire, United Kingdom
Aimun Ahmed, Dr
Not, yet, recruiting
Salford Royal Hospital
Salford, Lancashire, United Kingdom
Aine DeBhalis, Dr
Recruiting
Leicester General Hospital
Leicester, Leicestershire, United Kingdom
Osasuyi, Iyasere, Dr
Recruiting
St Helier Hospital
Carshalton, London, United Kingdom
Ayesha Irtiza-Ali, Dr
Not, yet, recruiting
Aintree University Hospital
Liverpool, Merseyside, United Kingdom
Chris Goldsmith, Dr
Recruiting
Norfolk and Norwich University Hospital
Norwich, Norfolk, United Kingdom
Matt Todd, Dr
Not, yet, recruiting
Antrim Area Hospital
Antrim, Northern Ireland, United Kingdom
Stephanie Bolton, Dr
Recruiting
Ulster Hospital
Belfast, Northern Ireland, United Kingdom
Alastair Woodman, Dr
Recruiting
Altnagelvin Hospital
Londonderry, Northern Ireland, United Kingdom
Frank McCarroll, Dr
Recruiting
Daisy Hill Hospital
Newry, Northern Ireland, United Kingdom
Neal Morgan, Dr
Not, yet, recruiting
Oxford Kidney Unit, Churchill Hospital,
Oxford, Oxfordshire, United Kingdom
Tom Connor, Dr
Recruiting
Doncaster Royal Infirmary
Doncaster, South Yorkshire, United Kingdom
Mohsen El Kossi, Dr
Recruiting
Sheffield Kidney Institute
Sheffield, South Yorkshire, United Kingdom
Ragada El-Damanawi, Dr
Recruiting
Royal Stoke University Hospital
Stoke-on-Trent, Staffordshire, United Kingdom
Dominic De Takats, Dr
Not, yet, recruiting
Freeman Hospital
Newcastle upon Tyne, Tyne and Wear, United Kingdom
John Sayer, Dr
Not, yet, recruiting
Queen Elizabeth Hospital Birmingham
Birmingham, West Midlands, United Kingdom
Yuki Heath, Dr
Not, yet, recruiting
Bradford Renal Unit, St Luke'S Hospital
Bradford, West Yorkshire, United Kingdom
Mohd Furqan, Dr
Recruiting
Cardiff and Vale University Health Board
Cardiff, United Kingdom
Recruiting
Epsom and St Helier University Hospitals
Carshalton, United Kingdom
Recruiting

9 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study — it may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 29 Nov 2022
Primary completion: 31 Dec 2030
Completion: 31 Dec 2030
Last update posted: 31 Mar 2026
Registered enrollment: 1,174
Registry id: NCT04939935

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 12 Jul 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.