Clinical trialNCT04969835RecruitingPhase 1Interventional

A Study Evaluating the Safety, Pharmacokinetics and Early Efficacy of AVA6000 in Solid Tumours

SponsorAvacta Life Sciences LtdEnrollment158Breast CancerOvarian CarcinomaSalivary Gland TumorSoft Tissue SarcomaUrothelial Carcinoma

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is a first-in-human (FIH), Phase 1 open-label, multicentre dose escalation study investigating AVA6000 monotherapy administered intravenously in patients with locally advanced (unresectable) or metastatic solid tumours that are likely to be FAP positive. The study consists of an initial Phase 1a dose escalation portion and a subsequent Phase 1b dose expansion portion upon completion of the dose escalation portion.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Chris Twelves, MD
St James's University Hospital, Leeds, UK
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

9 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United Kingdom

the Beatson West of Scotland Cancer Centre, Nhs Greater Glasgow & Clyde
Glasgow, United Kingdom
Professor Jeff Evans
Recruiting
St James'S University Hospital, the Leeds Teaching Hospitals Nhs Trust
Leeds, United Kingdom
Professor Chris Twelves
Recruiting
the Royal Marsden, Nhs Foundation Trust
London, United Kingdom
Professor Udai Banerji
Recruiting
the Christie Nhs Foundation Trust
Manchester, United Kingdom
Dr Natalie Cook
Recruiting
the Freeman Hospital, Newcastle-Upon-Tyne Nhs Foundation Trust
Newcastle upon Tyne, United Kingdom
Professor Ruth Plummer
Recruiting
Weston Park Cancer Centre, Sheffield Teaching Hospitals Nhs Foundation Trust
Sheffield, United Kingdom
Dr Robin Young
Not, yet, recruiting

United States

Memorial Sloan Kettering Cancer Center
New York, New York, United States
Dr William Tap
Recruiting
University of Texas Md Anderson Cancer Center
Houston, Texas, United States
Recruiting
Fred Hutchinson Cancer Center
Seattle, Washington, United States
Dr Jennifer Specht
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

AVA6000

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 16 Jul 2021
Primary completion: 15 Jun 2026
Completion: 15 Aug 2026
Last update posted: 15 May 2026
Registered enrollment: 158
Registry id: NCT04969835

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.