Clinical trialNCT04998396RecruitingPhase 1/PHASE2Interventional

A Study of AAV9 Gene Therapy in Participants With Canavan Disease (CANaspire Clinical Trial)

SponsorAspa TherapeuticsEnrollment26Canavan Disease

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The main objective of this trial is to evaluate the safety, tolerability, and pharmacodynamic activity of BBP-812, an investigational AAV9-based gene therapy, in pediatric participants with Canavan disease.

clinicaltrials.gov ↗

Investigators

No overall officials are registered on this study record. Site-level investigators, where published, appear with their sites below. Why? →

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

4 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Ucsf Benioff Children'S Hospital Oakland
Oakland, California, United States
Alexander Fay, MD
Recruiting
Ann & Robert H. Lurie Children'S Hospital of Chicago
Chicago, Illinois, United States
Jennifer Rubin, MD
Recruiting
Massachusetts General Hospital (mgh); Center for Rare Neurological Diseases (crnd)
Boston, Massachusetts, United States
Florian Eichler, MD
Recruiting
Weill Cornell Medicine; Division of Pediatric Neurology
New York, New York, United States
Completed

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

AAV9 BBP-812

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 8 Sept 2021
Primary completion: 13 Oct 2026
Completion: 8 Oct 2032
Last update posted: 17 Apr 2026
Registered enrollment: 26
Registry id: NCT04998396

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.