Clinical trialNCT05026749RecruitingPhase 3Interventional

Azithromycin Treatment for Respiratory Syncytial Virus-induced Respiratory Failure in Children

SponsorUniversity of Alabama at BirminghamEnrollment370Respiratory Syncytial Virus Infections

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The overarching hypothesis of the ARRC trial is that administration of Azithromycin (AZM) during acute, Respiratory Syncytial Virus (RSV)-induced respiratory failure will be beneficial, mediated through the matrix metalloproteinase (MMP)-9 pathway.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Michele Kong, MD
The University of Alabama at Birmingham
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

15 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

the University of Alabama at Birmingham
Birmingham, Alabama, United States
Michele Kong, MD
Recruiting
University of California San Francisco
San Francisco, California, United States
Recruiting
Yale School of Medicine
New Haven, Connecticut, United States
Recruiting
Children'S National Hospital
Washington D.C., District of Columbia, United States
Michael Shoykhet, MD
Recruiting
Ann & Robert H. Lurie Children'S Hospital of Chicago
Chicago, Illinois, United States
Recruiting
Riley Children'S Health
Indianapolis, Indiana, United States
Recruiting
St. Louis Children'S Hospital
St Louis, Missouri, United States
Recruiting
University of Nebraska Medical Center
Omaha, Nebraska, United States
Recruiting
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States
Recruiting
Rainbow Babies and Children'S Hospital
Cleveland, Ohio, United States
Recruiting
Nationwide Children'S Hospital
Columbus, Ohio, United States
Recruiting
Oklahoma Health Sciences
Oklahoma City, Oklahoma, United States
Recruiting
Children'S Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
Recruiting
the University of Texas Southwestern Medical Center
Dallas, Texas, United States
Recruiting
University of Utah
Salt Lake City, Utah, United States
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

AZM Group

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 27 Feb 2022
Primary completion: 1 Jul 2027
Completion: 31 Jul 2028
Last update posted: 9 Feb 2026
Registered enrollment: 370
Registry id: NCT05026749

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.