Clinical trialNCT05037123Active, not recruitingPhase 3Interventional

Optimizing the Use of Ketamine to Reduce Chronic Postsurgical Pain

SponsorNYU Langone HealthEnrollment765Chronic Postsurgical Pain

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The study utilizes a 3-arm placebo-controlled RCT to study the effectiveness of ketamine in reducing chronic post-mastectomy pain. Participants randomized to the first arm will receive a 0.35 mg/kg dose after induction, followed by a 0.25 mg/kg/hr infusion during surgery (up to a maximum of 6 hours) and continued for 2 hours postoperatively. Participants in the second arm will receive a single dose of 0.6 mg/kg of ketamine in the post-anesthesia care unit, and the final group will serve as the control group and receive saline (no ketamine).

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Jing Wang, MD, PhD
NYU Langone Health
Principal Investigator
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Lisa Doan, MD
NYU Langone Health
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

14 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Alabama at Birmingham
Birmingham, Alabama, United States
University of Arkansas
Little Rock, Arkansas, United States
Rush University Medical Center
Chicago, Illinois, United States
Brigham and Women'S Hospital - Harvard University
Chestnut Hill, Massachusetts, United States
Mayo Clinic
Rochester, Minnesota, United States
Washington University at St. Louis Medical Center
St Louis, Missouri, United States
Memorial Sloan Kettering Cancer Center
New York, New York, United States
Nyu Langone Health (tisch Hospital, Kimmel Pavilion)
New York, New York, United States
New York Presbyterian Columbia University Irving Medical Center
New York, New York, United States
Montefiore Medical Center - Albert Einstein College of Medicine
The Bronx, New York, United States
University of Pittsburgh - Magee Women'S Hospital
Pittsburgh, Pennsylvania, United States
University of Texas - Southwestern Medical Center
Dallas, Texas, United States
University of Texas - Md Anderson Cancer Center
Houston, Texas, United States
University of Washington Medical Center
Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Continuous ketamine infusionKetamine + Saline

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 4 Jan 2022
Primary completion: 28 May 2025
Completion: 31 Aug 2026
Last update posted: 8 Jun 2026
Registered enrollment: 765
Registry id: NCT05037123

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.