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Clinical trialNCT05048875CompletedPhase 2Interventional

An Evaluation of Repeated Oral Doses of JNJ-64281802 Against DENV-3 Challenge

SponsorNational Institute of Allergy and Infectious Diseases (NIAID)Enrollment56Dengue
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The investigational study drug, JNJ-64281802, is being developed for the prevention and treatment of dengue infection. This study is hypothesizing that the highest dose of the investigational study drug is superior to receiving a placebo with respect to its antiviral activity in healthy adult participants inoculated with Dengue Serotype 3.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

  • Anna Durbin, MD

    Center for Immunization Research, Johns Hopkins School of Public Health

    Principal Investigator
    clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

2 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Johns Hopkins University, Bloomberg School of Public Health

    Baltimore, Maryland, United States

  • University of Vermont Medical Center (uvmmc), Clinical Research Center

    Burlington, Vermont, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Cohort 1 - Group 1 JNJ High DoseCohort 1 - Group 1/2 PlaceboCohort 1 - Group 2 JNJ Low DoseCohort 1 - Group 2 JNJ Medium Dose
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
3 Feb 2022
Primary completion
16 May 2023
Completion
10 Sept 2024
Last update posted
24 Apr 2025
Registered enrollment
56
Registry id
NCT05048875
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.