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Clinical trialNCT05081128Active, not recruitingInterventional

Efficacy in iNPH Shunting (PENS) Trial

SponsorJohns Hopkins UniversityEnrollment100Idiopathic Normal Pressure Hydrocephalus (INPH)
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The Placebo-Controlled Efficacy in Idiopathic Normal Pressure Hydrocephalus (iNPH) Shunting (PENS) trial is a multi-center blinded, randomized, placebo-controlled design investigation of cerebrospinal fluid (CSF) shunt surgery to study the shunt efficacy in iNPH patients.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

17 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada
  • University of Calgary

    Calgary, Alberta, Canada

  • University of British Columbia

    Vancouver, Canada

Sweden
  • Umeå University

    Umeå, Sweden

United States
  • University of California, Davis

    Davis, California, United States

  • University of Southern California

    Los Angeles, California, United States

  • Pacific Neuroscience Institute

    Santa Monica, California, United States

  • University of South Florida

    Tampa, Florida, United States

  • Emory University

    Atlanta, Georgia, United States

  • Indiana University

    Indianapolis, Indiana, United States

  • Johns Hopkins University

    Baltimore, Maryland, United States

  • Mayo Clinic

    Rochester, Minnesota, United States

  • Mount Sinai Health System

    New York, New York, United States

  • New York University Langone Health

    New York, New York, United States

  • Wake Forest Baptist Medical Center

    Winston-Salem, North Carolina, United States

  • Oregon Health & Science University

    Portland, Oregon, United States

  • the University of Texas Southwestern Medical Center

    Dallas, Texas, United States

  • University of Washington

    Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
18 May 2022
Primary completion
31 May 2027
Completion
31 Aug 2027
Last update posted
8 May 2026
Registered enrollment
100
Registry id
NCT05081128

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.