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Clinical trialNCT05101551RecruitingPhase 1Interventional

Study of Talazoparib in Combination With Chemotherapy in Relapsed Pediatric AML to Determine Safety and Efficacy

SponsorNorman J. LacayoEnrollment34Acute Myeloid Leukemia
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is a Phase 1, open label, multicenter, dose finding study with dose expansion intended to evaluate the safety and tolerability of talazoparib in combination with conventional chemotherapy. Preliminary estimates of efficacy will be obtain through a dose expansion cohort receiving the maximum tolerated dose from the dose escalation phase of the study. This study aims to determine the safety of talazoparib in combination with conventional chemotherapy and to establish the maximum tolerated dose of all 3 drugs when given in combination. A preliminary estimate of efficacy through a dose expansion phase is a secondary aim.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

9 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Phoenix Children'S Hospital

    Phoenix, Arizona, United States

    Laura Retson, DO
    Recruiting
  • Arkansas Children'S Hospital

    Little Rock, Arkansas, United States

    Kevin J Bielamowicz, MD
    Recruiting
  • City of Hope

    Duarte, California, United States

    Lindsey Murphy, MD
    Recruiting
  • Stanford University

    Stanford, California, United States

    Norman LacayoTanja Gruber
    Recruiting
  • Cincinnati Children'S Hospital

    Cincinnati, Ohio, United States

    Jennifer Kamens, MD
    Recruiting
  • Pennsylvania State University Hershey Medical Center

    Hershey, Pennsylvania, United States

    Valerie Brown, MD, PhD
    Recruiting
  • St. Jude Children'S Research Hospital

    Memphis, Tennessee, United States

    Seth Karol, MD
    Recruiting
  • University of Utah

    Salt Lake City, Utah, United States

    Spencer Mangum, MD
    Recruiting
  • University of Wisconsin Carbone Cancer Center

    Madison, Wisconsin, United States

    Rebecca Richards, MD
    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Gemcitabine →Talazoparib →Topotecan →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
23 Feb 2023
Primary completion
30 Apr 2027
Completion
30 Apr 2027
Last update posted
22 Apr 2026
Registered enrollment
34
Registry id
NCT05101551
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.