Clinical trialNCT05118789RecruitingPhase 1/PHASE2Interventional

A Study of Zidesamtinib (NVL-520) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1)

SponsorNuvalent Inc.Enrollment359Locally Advanced Solid TumorMetastatic Solid Tumor

View the registry record on ClinicalTrials.gov

Summary

The registered summary isn't in our current data snapshot. Read it on the ClinicalTrials.gov record ↗. Why? →

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Vivek Upadhyay, MD, MBI
Nuvalent Inc.
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

63 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia

Chris O'Brien Lifehouse
Camperdown, New South Wales, Australia
Steven Kao, PhD
Recruiting
Peter Maccallum Cancer Centre
Melbourne, Victoria, Australia
Ben Solomon, MD, PhD
Recruiting

Belgium

University Hospital Leuven
Leuven, Belgium
Christophe Dooms, MD, PhD
Recruiting

Canada

Cross Cancer Institute
Edmonton, Alberta, Canada
Quincy Chu, MD
Recruiting
Princess Margaret Cancer Research
Toronto, Ontario, Canada
Geoffrey Liu, MD
Recruiting

France

Centre Legon Berard
Lyon, France
Aurelie Swalduz, MD
Recruiting
Chu de Nantes
Nantes, France
Elvire Pons-Tostivint, MD, PhD
Recruiting
Claudius Regaud Institute
Toulouse, France
Julien Mazieres, MD, PhD
Recruiting
Institute Gustave Roussy
Villejuif, France
Benjamin Besse, MD, PhD
Recruiting

Germany

Cologne University Hospital
Cologne, Germany
Juergen Wolf, MD
Recruiting

Italy

Università Politecnica Marche
Ancona, Italy
Rossana Berardi, MD
Recruiting
Irccs Istituto Tumori Giovanni Paolo Ii
Bari, Italy
Domenico Galetta, MD, PhD
Recruiting
Fondazione Irccs Istituto Nazionale Dei Tumori
Milan, Italy
Matteo Duca, MD
Recruiting
Istituto Europeo Di Oncologia
Milan, Italy
Gianluca Spitaleri, MD
Recruiting
Istituto Oncologico Veneto
Padova, Italy
Giulia Pasello, MD, PhD
Recruiting
Ospedale Santa Maria Delle Croci
Ravenna, Italy
Chiara Bennati, MD
Recruiting
Istituto Nazionale Tumori Regina Elena
Rome, Italy
Lorenza Landi, MD
Recruiting

Japan

Kanagawa Cancer Center
Kanagawa, Japan
Tetsuro Kondo, MD
Recruiting
Okayama University Hospital
Okayama, Japan
Kiichiro Ninomiya, MD, PhD
Recruiting
Kindai University Hospital
Osaka, Japan
Hidetoshi Hayashi, MD, PhD
Recruiting
Shizuoka Cancer Center
Shizuoka, Japan
Ryo Ko, MD, PhD
Recruiting
National Cancer Center Hospital
Tokyo, Japan
Tatsuya Yoshida, MD, PhD
Recruiting
the Cancer Institute Hospital of Jfcr
Tokyo, Japan
Ryo Ariyasu, MD
Recruiting
Wakayama Medical University Hospital
Wakayama, Japan
Hiroaki Akamatsu, MD, PhD
Recruiting

Netherlands

Netherlands Cancer Institute
Amsterdam, Netherlands
Joop de Langen, MD, PhD
Recruiting
University Medical Centre Groningen
Groningen, Netherlands
Anthonie van der Wekken, MD, PhD
Recruiting

Singapore

National Cancer Centre Singapore
Singapore, Singapore
Daniel Tan, PhD
Recruiting
National University Hospital Singapore
Singapore, Singapore
Ross A Soo, MD
Recruiting

South Korea

National Cancer Center
Gyeonggi-do, South Korea
Ji-Youn Han, MD
Recruiting
Samsung Medical Center
Seoul, South Korea
Myung-Ju Ahn, MD, PhD
Recruiting
Seoul National University Hospital
Seoul, South Korea
Dong-Wan Kim, MD, PhD
Recruiting
Yonsei University Health System
Seoul, South Korea
Byoung Chul Cho, MD, PhD
Recruiting

Spain

University Hospital of A Coruña
A Coruña, Spain
Maria Campelo, MD
Recruiting
Uomi Cancer Center - Clinica Tres Torres
Barcelona, Spain
Santiago Viteri, MD
Recruiting
Vall D'Hebron University Hospital
Barcelona, Spain
Enriqueta Felip, MD, PhD
Recruiting
Gregorio Marañón Hospital
Madrid, Spain
Antonio Calles, MD
Recruiting
Hospital Universitario 12 de Octubre
Madrid, Spain
Luis Paz-Ares, MD, PhD
Recruiting
Hospital Universitario Hm Sanchinarro
Madrid, Spain
Ramon Yarza, MD, MBI, MSc
Recruiting

Taiwan

Chung Shan Medical University Hospital
Taichung, Taiwan
Gee Chen Chang, MD, PhD
Recruiting
National Cheng Kung University Hospital
Tainan, Taiwan
Chien-Chung Lin, MD, PhD
Recruiting

23 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Zidesamtinib

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 4 Jan 2022
Primary completion: 31 Dec 2027
Completion: 31 Dec 2028
Last update posted: 24 Oct 2025
Registered enrollment: 359
Registry id: NCT05118789

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 12 Jul 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.