findmyKOL
Clinical trialNCT05140941Active, not recruitingPhase 4Interventional

Sofosbuvir/Velpatasvir Treatment of Chronic Hepatitis C During Pregnancy

SponsorCatherine Anne ChappellEnrollment100Hepatitis C, ChronicPregnancy; Infection
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is a multicenter, single arm study of Sofosbuvir/Velpatasvir (SOF/VEL) for treatment of chronic hepatitis C infection during pregnancy. Treatment will be initiated during the second or third trimester in approximately 100 pregnant people. Maternal participants will take one SOF/VEL tablet once daily for 12 weeks (84 days) and followed until 12 weeks after treatment completion (postpartum). Infants will be followed from birth until one year of age. The primary objectives are to evaluate the sustained virologic response 12 weeks after completion of SOF/VEL treatment (SVR12) in participants treated during pregnancy and to evaluate impact of antenatal treatment with SOF/VEL on the gestational age at delivery.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

9 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada
  • Victoria Hospital, London Health Sciences Center

    London, Ontario, Canada

  • Toronto General Hospital, University Health Network

    Toronto, Ontario, Canada

  • University Health Toronto, St Michaels Hospital

    Toronto, Ontario, Canada

United States
  • the Christ Hospital

    Cincinnati, Ohio, United States

  • the Ohio State University Wexner Medical Center

    Columbus, Ohio, United States

  • University of Pittsburgh, Magee Womens Hospital

    Pittsburgh, Pennsylvania, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, United States

  • University of Utah

    Salt Lake City, Utah, United States

  • Marshall University

    Huntington, West Virginia, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Sofosbuvir / velpatasvir →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
4 Apr 2022
Primary completion
31 Aug 2026
Completion
30 Jun 2027
Last update posted
15 Apr 2026
Registered enrollment
100
Registry id
NCT05140941
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.