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Clinical trialNCT05147571CompletedInterventional

RNS System NAUTILUS Study

SponsorNeuroPaceEnrollment100EpilepsyGeneralized Tonic Clonic SeizureIdiopathic Generalized Epilepsy
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

To demonstrate that the RNS System for thalamic stimulation is safe and effective as an adjunctive therapy for the reduction of primary generalized seizures in individuals 12 years of age or older who have drug-resistant idiopathic generalized epilepsy.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

23 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • University of Alabama at Birmingham

    Birmingham, Alabama, United States

  • Mayo Clinic - Arizona

    Phoenix, Arizona, United States

  • University of Colorado

    Aurora, Colorado, United States

  • Nicklaus Children'S Hospital

    Miami, Florida, United States

  • University of South Florida

    Tampa, Florida, United States

  • Indiana University Health

    Indianapolis, Indiana, United States

  • University of Kansas Medical Center

    Kansas City, Kansas, United States

  • University of Louisville

    Louisville, Kentucky, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, United States

  • Spectrum Health Butterworth Hospital

    Grand Rapids, Michigan, United States

  • Mayo Clinic - Rochester

    Rochester, Minnesota, United States

  • Washington University

    St Louis, Missouri, United States

  • Mary Hitchcock Memorial Hospital (dartmouth)

    Lebanon, New Hampshire, United States

  • University of New Mexico

    Albuquerque, New Mexico, United States

  • New York University Langone

    New York, New York, United States

  • Oregon Health and Science University

    Portland, Oregon, United States

  • Thomas Jefferson University

    Philadelphia, Pennsylvania, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, United States

  • Upmc

    Pittsburgh, Pennsylvania, United States

  • Vanderbilt University Medical Center

    Nashville, Tennessee, United States

  • Baylor College of Medicine

    Houston, Texas, United States

  • the University of Texas Health Science Center at Houston

    Houston, Texas, United States

  • University of Utah Healthcare

    Salt Lake City, Utah, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
9 Aug 2022
Primary completion
4 Apr 2025
Completion
31 Mar 2026
Last update posted
8 Jun 2026
Registered enrollment
100
Registry id
NCT05147571

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.