Clinical trialNCT05172245RecruitingPhase 1Interventional

Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck Cancer

SponsorNational Cancer Institute (NCI)Enrollment46Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8Head and Neck Carcinoma of Unknown PrimaryLocally Advanced Head and Neck Squamous Cell CarcinomaLocally Advanced Hypopharyngeal Squamous Cell CarcinomaLocally Advanced Laryngeal Squamous Cell CarcinomaLocally Advanced Nasal Cavity Squamous Cell Carcinoma+20 more conditions

View the registry record on ClinicalTrials.gov

Summary

The registered summary isn't in our current data snapshot. Read it on the ClinicalTrials.gov record ↗. Why? →

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Malcolm D Mattes
University Health Network Princess Margaret Cancer Center LAO
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

18 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada

University Health Network-Princess Margaret Hospital
Toronto, Ontario, Canada
Suspended

United States

Moffitt Cancer Center
Tampa, Florida, United States
George Q. Yang
Recruiting
Northwestern University
Chicago, Illinois, United States
Laila A. Gharzai
Recruiting
University of Kansas Clinical Research Center
Fairway, Kansas, United States
Christopher Lominska
Recruiting
University of Kansas Cancer Center
Kansas City, Kansas, United States
Christopher Lominska
Recruiting
University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas, United States
Christopher Lominska
Recruiting
University of Kentucky/markey Cancer Center
Lexington, Kentucky, United States
Active, not recruiting
University of Maryland/greenebaum Cancer Center
Baltimore, Maryland, United States
Ranee Mehra
Recruiting
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, United States
Malcolm D. Mattes
Recruiting
Rutgers New Jersey Medical School
Newark, New Jersey, United States
Malcolm D. Mattes
Recruiting
Montefiore Medical Center - Moses Campus
The Bronx, New York, United States
Rafi Kabarriti
Recruiting
Montefiore Medical Center-Einstein Campus
The Bronx, New York, United States
Rafi Kabarriti
Recruiting
Carolinas Medical Center/levine Cancer Institute
Charlotte, North Carolina, United States
Active, not recruiting
Atrium Health Cabarrus/lci-Concord
Concord, North Carolina, United States
Active, not recruiting
University of Cincinnati Cancer Center-Uc Medical Center
Cincinnati, Ohio, United States
Trisha M. Wise-Draper
Recruiting
University of Cincinnati Cancer Center-West Chester
West Chester, Ohio, United States
Trisha M. Wise-Draper
Recruiting
University of Virginia Cancer Center
Charlottesville, Virginia, United States
Suspended
Vcu Massey Comprehensive Cancer Center
Richmond, Virginia, United States
Erin R. Alesi
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study — it may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 19 Sept 2022
Primary completion: 1 Jul 2027
Completion: 1 Jul 2027
Last update posted: 18 May 2026
Registered enrollment: 46
Registry id: NCT05172245

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 12 Jul 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.