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Clinical trialNCT05176626Active, not recruitingPhase 4Interventional

Long-term Effectiveness of the Antiobesity Medication Phentermine

SponsorWake Forest University Health SciencesEnrollment870Lifestyle, HealthyObesityObesity; Drug
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this research study is to understand the long-term effects of the drug phentermine on weight, blood pressure, other health outcomes, and safety. Phentermine has been approved by the US Food and Drug Administration (FDA) for weight management since 1959, but it has not been approved for long-term use (i.e., treatment lasting more than 12 weeks). This trial is designed to learn about the long-term effects of phentermine for up to 2 years because obesity is a chronic disease and expert guidelines recommend long-term use of anti-obesity medications as one treatment option.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

4 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Kaiser Permanente Southern California

    Los Angeles, California, United States

  • Healthpartners Institute

    Saint Louis Park, Minnesota, United States

  • Atrium Health Wake Forest Baptist Weight Management Center

    Winston-Salem, North Carolina, United States

  • Ut Center for Obesity Medicine and Metabolic Performance

    Bellaire, Texas, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Phentermine
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
30 Jun 2022
Primary completion
31 Dec 2026
Completion
31 Dec 2026
Last update posted
31 Mar 2026
Registered enrollment
870
Registry id
NCT05176626
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.