Clinical trialNCT05204329CompletedEarly phase 1Interventional

Safety of Topical Mesenchymal Stromal Cell Secretome for Ocular Surface Disease

SponsorUniversity of Illinois at ChicagoEnrollment9CorneaCorneal DefectCorneal Epithelium DefectMesenchymal Stromal Cells

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This study is a longitudinal assessment using a classic dose-escalation study design to assess the safety and maximal tolerated dose (MTD) of topical MSC Secretome eye drops. The study will be conducted at Illinois Eye and Ear Infirmary located at University of Illinois at Chicago. The study will use anterior segment Optical Coherence Tomography (OCT)/Scheimpflug Imaging, esthesiometry, and visual analogue scale (VAS) to assess treatment tolerability.

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Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Ali R Djalilian, MD
University of Illinois at Chicago
Principal Investigator
clinicaltrials.gov ↗
Charlotte E Joslin, OD, PhD
University of Illinois at Chicago
Principal Investigator
clinicaltrials.gov ↗
Elmer Y Tu, MD
University of Illinois at Chicago
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

1 registered facility, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of Illinois at Chicago
Chicago, Illinois, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

MSC Secretome Eye Drops

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 24 Jan 2024
Primary completion: 8 Nov 2024
Completion: 8 Nov 2024
Last update posted: 29 Jan 2026
Registered enrollment: 9
Registry id: NCT05204329

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.