Clinical trialNCT05208190RecruitingPhase 4Interventional

Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical Trial

SponsorNew York State Psychiatric InstituteEnrollment280Schizoaffective DisorderSchizophrenia

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

Two-hundred and eighty individuals with schizophrenia who have a recent history of violent acts will be randomized in this 2-arm, parallel-group, 24-week, open-label, 7-site clinical trial to examine the effects of treatment with clozapine vs antipsychotic treatment as usual (TAU) for reducing the risk of violent acts in real-world settings

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Ragy Girgis, MD
New York State Psychiatric Institute
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

7 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

University of California, Los Angeles
Los Angeles, California, United States
Recruiting
Augusta University Research Institute, Inc.
Augusta, Georgia, United States
Recruiting
University of Maryland School of Medicine
Baltimore, Maryland, United States
Recruiting
Manhattan Psychiatric Center
New York, New York, United States
Recruiting
Nyu Langone Medical Center
New York, New York, United States
Recruiting
New York State Psychiatric Institute
New York, New York, United States
Ragy R Girgis, MDScott Stroup, MD
Recruiting
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Clozapine →Treatment as usual

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 17 Mar 2022
Primary completion: 30 Jun 2028
Completion: 31 Dec 2028
Last update posted: 4 May 2026
Registered enrollment: 280
Registry id: NCT05208190

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.