Clinical trialNCT05222620RecruitingPhase 2Interventional

SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial

SponsorMayo ClinicEnrollment90Metastatic Malignant Neoplasm in the BrainMetastatic Malignant Solid Neoplasm

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase II trial compares the effect of single fraction stereotactic radiosurgery to fractionated stereotactic radiosurgery for the treatment of patients with cancer that has spread to the brain (metastatic brain disease). Stereotactic radiosurgery (SRS) is a form of radiation therapy that focuses high-power energy on a small area of the body. This trial is being done to determine if single (one) fraction stereotactic radiosurgery is better than fractionated stereotactic radiosurgery or vice versa in controlling tumor and side effects in patients with tumors that have spread to the brain.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Paul D. Brown, MD
Mayo Clinic in Rochester
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

7 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Mayo Clinic in Arizona
Scottsdale, Arizona, United States
Sujay A. Vora, MD
Recruiting
Mayo Clinic in Florida
Jacksonville, Florida, United States
Jennifer L. Peterson, MD
Recruiting
Mayo Clinic Health System in Albert Lea
Albert Lea, Minnesota, United States
John Yeakel, MD
Not, yet, recruiting
Mayo Clinic Health Systems-Mankato
Mankato, Minnesota, United States
Jason T. Hayes, MD
Recruiting
Mayo Clinic in Rochester
Rochester, Minnesota, United States
Paul D. Brown, M.D.
Recruiting
Mayo Clinic Health System-Eau Claire Clinic
Eau Claire, Wisconsin, United States
Now Bahar Alam, MD
Recruiting
Mayo Clinic Health System-Franciscan Healthcare
La Crosse, Wisconsin, United States
Abigail L. Stockham, MD
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 14 Mar 2022
Primary completion: 15 Feb 2027
Completion: 15 Feb 2028
Last update posted: 13 Apr 2026
Registered enrollment: 90
Registry id: NCT05222620

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.