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Clinical trialNCT05229900TerminatedPhase 1Interventional

A Study of SGN-ALPV in Advanced Solid Tumors

SponsorSeagen Inc.Enrollment43Carcinoma, Non-Small-Cell LungEndometrial NeoplasmsGastroesophageal Junction CarcinomaOvarian NeoplasmsStomach NeoplasmsTesticular Neoplasms+1 more conditions
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This study will test the safety of a drug called SGN-ALPV in participants with solid tumors. It will also study the side effects of this drug. A side effect is anything a drug does to your body besides treating your disease. Participants will have solid tumor cancer that has spread through the body (metastatic) or cannot be removed with surgery (unresectable). This study will have three parts. Parts A and B of the study will find out how much SGN-ALPV should be given to participants. Part C will use the dose and schedule found in Parts A and B to find out how safe SGN-ALPV is and if it works to treat solid tumor cancers.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

13 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada
  • Ottawa Hospital Cancer Centre

    Ottawa, Ontario, Canada

  • University Health Network, Princess Margaret Hospital

    Toronto, Ontario, Canada

Spain
  • Start Madrid-Ciocc_hospital Hm Sanchinarro

    Madrid, Other, Spain

Sweden
  • Karolinska University Hospital

    Stockholm, Other, Sweden

United Kingdom
  • Sarah Cannon Research Institute Uk

    London, Other, United Kingdom

  • the Royal Marsden Nhs Foundation Trust (rm)

    London, Other, United Kingdom

United States
  • Women'S Cancer Care

    Fresno, California, United States

  • Yale Cancer Center

    New Haven, Connecticut, United States

  • Florida Cancer Specialists - Lake Nona

    Wellington, Florida, United States

  • Start Midwest

    Grand Rapids, Michigan, United States

  • Oklahoma University at Stephenson Cancer Center

    Oklahoma City, Oklahoma, United States

  • Start Mountain Region

    West Valley City, Utah, United States

  • Virginia Cancer Specialists

    Fairfax, Virginia, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

SGN-ALPV
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
21 Apr 2022
Primary completion
13 Dec 2023
Completion
13 Dec 2023
Last update posted
10 Feb 2025
Registered enrollment
43
Registry id
NCT05229900
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.