Clinical trialNCT05230173RecruitingInterventional

Treat-to-Target of Endoscopic Remission in Patients With IBD in Symptomatic Remission

SponsorMayo ClinicEnrollment216Crohn DiseaseUlcerative Colitis

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to compare the effectiveness and safety of a strategy of switching to an alternative targeted immunomodulator (TIM) therapy to treat to a target of endoscopic remission, versus continuing index TIM in patients with inflammatory bowel disease (IBD) (Crohn's disease or ulcerative colitis \[UC\]) in symptomatic remission with moderate to severe endoscopic inflammation despite optimization of index TIM in a real-world setting.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Siddharth Singh, MD
Mayo Clinic
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

24 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Mayo Clinic Arizona
Scottsdale, Arizona, United States
Siddharth Singh, MD
Recruiting
Hoag Hospital
Irvine, California, United States
Caroline Hwang, MD
Recruiting
Uc San Diego Health
La Jolla, California, United States
Brigid Boland, MD
Recruiting
Cedars-Sinai
Los Angeles, California, United States
Gil Melmed, MD
Recruiting
Sutter Health
Palo Alto, California, United States
Ryan McConnell, MD
Recruiting
University of Colorado
Aurora, Colorado, United States
Mark Gerich, MD
Recruiting
Yale University
New Haven, Connecticut, United States
Jill Gaidos, MD
Recruiting
Medstar Georgetown University Hospital
Washington D.C., District of Columbia, United States
Mark Mattar, MD
Recruiting
Mayo Clinic Jacksonville
Jacksonville, Florida, United States
Jana Al Hashash, MD
Recruiting
Advent Health
Orlando, Florida, United States
Jennifer Seminerio-Diehl, MD
Recruiting
University of Chicago Medicine
Chicago, Illinois, United States
David Rubin, MD
Recruiting
Dartmouth Hitchcock
Lebanon, New Hampshire, United States
Corey Siegel, MD
Recruiting
Saratoga Schenectady Gastroenterology Associates
Burnt Hills, New York, United States
Mark Metwally, MD
Recruiting
Cornell University
New York, New York, United States
Dana Lukin, MD
Recruiting
Nyu Langone Health
New York, New York, United States
David Hudesman, MD
Recruiting
University of Rochester
Rochester, New York, United States
Terminated
Hightower Clinical
Oklahoma City, Oklahoma, United States
Active, not recruiting
Oregon Clinic
Portland, Oregon, United States
Withdrawn
Gastroenterology Associates
Providence, Rhode Island, United States
Samir Shah, MD
Recruiting
Gastroone
Germantown, Tennessee, United States
Withdrawn
University of Texas Southwestern
Dallas, Texas, United States
David Fudman, MD
Recruiting
Baylor College of Medicine
Houston, Texas, United States
Jason Hou, MD
Recruiting
University of Utah Health
Salt Lake City, Utah, United States
Ann Flynn, MD
Recruiting
University of Virginia
Charlottesville, Virginia, United States
Withdrawn

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 5 Oct 2022
Primary completion: 1 Aug 2028
Completion: 1 Feb 2029
Last update posted: 7 Aug 2026
Registered enrollment: 216
Registry id: NCT05230173

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.