Clinical trialNCT05235165RecruitingPhase 3Interventional

Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

SponsorChildren's Oncology GroupEnrollment62Metastatic Malignant Neoplasm in the LungMetastatic OsteosarcomaOsteosarcoma

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase III trial compares the effect of open thoracic surgery (thoracotomy) to thoracoscopic surgery (video-assisted thoracoscopic surgery or VATS) in treating patients with osteosarcoma that has spread to the lung (pulmonary metastases). Open thoracic surgery is a type of surgery done through a single larger incision (like a large cut) that goes between the ribs, opens up the chest, and removes the cancer. Thoracoscopy is a type of chest surgery where the doctor makes several small incisions and uses a small camera to help with removing the cancer. This trial is being done evaluate the two different surgery methods for patients with osteosarcoma that has spread to the lung to find out which is better.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

John J Doski
Children's Oncology Group
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

233 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia

the Children'S Hospital at Westmead
Westmead, New South Wales, Australia
Suspended
Royal Children'S Hospital
Parkville, Victoria, Australia
Suspended
Perth Children'S Hospital
Perth, Western Australia, Australia
Suspended

Canada

Alberta Children'S Hospital
Calgary, Alberta, Canada
Victor A. Lewis
Recruiting
University of Alberta Hospital
Edmonton, Alberta, Canada
Sarah J. McKillop
Recruiting
Iwk Health Centre
Halifax, Nova Scotia, Canada
Chelsea Ash
Recruiting
Centre Hospitalier Universitaire Sainte-Justine
Montreal, Quebec, Canada
Monia Marzouki
Recruiting
the Montreal Children'S Hospital of the Muhc
Montreal, Quebec, Canada
Stephanie Mourad
Recruiting
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
Sherbrooke, Quebec, Canada
Josee Brossard
Recruiting

New Zealand

Starship Children'S Hospital
Grafton, Auckland, New Zealand
Mandy PohLui de Silva
Recruiting
Christchurch Hospital
Christchurch, New Zealand
Tristan Pettit
Recruiting

Puerto Rico

Hima San Pablo Oncologic Hospital
Caguas, Puerto Rico
Active, not recruiting

Saudi Arabia

King Faisal Specialist Hospital and Research Centre
Riyadh, Saudi Arabia
Suspended

United States

Children'S Hospital of Alabama
Birmingham, Alabama, United States
Jamie M. Aye
Recruiting
Providence Alaska Medical Center
Anchorage, Alaska, United States
Brenda J. Wittman
Recruiting
Kingman Regional Medical Center
Kingman, Arizona, United States
Alan K. Ikeda
Recruiting
Banner Children'S at Desert
Mesa, Arizona, United States
Joseph C. Torkildson
Recruiting
Phoenix Childrens Hospital
Phoenix, Arizona, United States
Alok K. Kothari
Recruiting
Banner University Medical Center - Tucson
Tucson, Arizona, United States
Michelina de la Maza
Recruiting
Arkansas Children'S Hospital
Little Rock, Arkansas, United States
Michael W. Bishop
Recruiting
Kaiser Permanente-Anaheim
Anaheim, California, United States
Robert M. Cooper
Recruiting
Pcr Oncology
Arroyo Grande, California, United States
Alan K. Ikeda
Recruiting
Kaiser Permanente-Bellflower
Bellflower, California, United States
Robert M. Cooper
Recruiting
Kaiser Permanente Downey Medical Center
Downey, California, United States
Robert M. Cooper
Recruiting
Kaiser Permanente-Fontana
Fontana, California, United States
Robert M. Cooper
Recruiting
Loma Linda University Medical Center
Loma Linda, California, United States
Albert Kheradpour
Recruiting
Miller Children'S and Women'S Hospital Long Beach
Long Beach, California, United States
Jacqueline N. Casillas
Recruiting
Cedars-Sinai Medical Center
Los Angeles, California, United States
Leo Mascarenhas
Recruiting
Children'S Hospital Los Angeles
Los Angeles, California, United States
Fariba Navid
Recruiting
Kaiser Permanente Los Angeles Medical Center
Los Angeles, California, United States
Robert M. Cooper
Recruiting
Valley Children'S Hospital
Madera, California, United States
Ruetima Titapiwatanakun
Recruiting
Kaiser Permanente-Oakland
Oakland, California, United States
Aarati V. Rao
Recruiting
Children'S Hospital of Orange County
Orange, California, United States
Elyssa M. Rubin
Recruiting
Lucile Packard Children'S Hospital Stanford University
Palo Alto, California, United States
Jay Michael S. Balagtas
Recruiting
University of California Davis Comprehensive Cancer Center
Sacramento, California, United States
Marcio H. Malogolowkin
Recruiting
Kaiser Permanente-San Diego Zion
San Diego, California, United States
Robert M. Cooper
Recruiting
Rady Children'S Hospital - San Diego
San Diego, California, United States
William D. Roberts
Recruiting
Ucsf Medical Center-Mission Bay
San Francisco, California, United States
Arun A. Rangaswami
Recruiting
Children'S Hospital Colorado
Aurora, Colorado, United States
Jonathan P. Roach
Recruiting
Rocky Mountain Hospital for Children-Presbyterian Saint Luke'S Medical Center
Denver, Colorado, United States
Florence Choo
Recruiting

193 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 1 Apr 2022
Primary completion: 31 Mar 2031
Completion: 31 Mar 2031
Last update posted: 25 Aug 2026
Registered enrollment: 62
Registry id: NCT05235165

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.