Clinical trialNCT05254743RecruitingPhase 3Interventional

A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

SponsorLoxo Oncology, Inc.Enrollment737Chronic Lymphocytic LeukemiaLeukemia, B-cellLeukemia, LymphocyticSmall Lymphocytic Lymphoma

View the registry record on ClinicalTrials.gov

Summary

The registered summary isn't in our current data snapshot. Read it on the ClinicalTrials.gov record ↗. Why? →

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST)
Eli Lilly and Company
Study Director
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

143 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Argentina

Alexander Fleming
Ciudad Autónoma de Buenos Aire, Argentina
María Del Rosario Custidiano
Recruiting
Hospital Privado de Comunidad
Mar del Plata, Argentina
Active, not recruiting
Clínica de Nefrología, Urología Y Enfermedades Cardiovasculares
Santa Fe, Argentina
Manuela Moreira Rodriguez
Recruiting

Australia

One Clinical Research
Nedlands, Australia
Active, not recruiting
Western Health, Sunshine Hospital
St Albans, Australia
Active, not recruiting
the Perth Blood Institute
West Perth, Australia
Ross Baker
Recruiting

Austria

Hanusch Krankenhaus
Vienna, Austria
Active, not recruiting

Belgium

Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg
Leuven, Belgium
Ann Janssens
Recruiting
Vitaz
Sint-Niklaas, Belgium
Vanessa Van Hende
Recruiting

Brazil

Fundação Pio Xii - Hospital de Câncer de Barretos
Barretos, Brazil
Nelson Siqueira de Castro
Recruiting
Upeclin - Unidade de Pesquisa Clínica Da Faculdade de Medicina de Botucatu - Unesp
Botucatu, Brazil
Rafael Dezen Gaiolla
Recruiting
Hemocentro Unicamp
Campinas, Brazil
Fernando Vieira Pericole de Souza
Recruiting
Hospital Uopeccan - Centro de Pesquisa Clinica
Cascavel, Brazil
Gabriela Almeida Garcia
Recruiting
Centro Integrado de Oncologia de Curitiba
Curitiba, Brazil
Active, not recruiting
Hospital Erasto Gaertner - Liga Paranaense de Combate Ao Câncer
Curitiba, Brazil
João Samuel de Holanda Farias
Recruiting
Instituto Do Câncer - Hospital São Vicente de Paulo
Passo Fundo, Brazil
Moema Nene Santos
Recruiting
Centro Gaucho Integrado - Mae de Deus Center
Porto Alegre, Brazil
Marcelo Capra
Recruiting
Hospital de Clínicas de Ribeirão Preto
Ribeirão Preto, Brazil
Diego Villa Clé
Recruiting
Cepho - Centro de Estudos E Pesquisas de Hematologia E Oncologia
Santo André, Brazil
Debora Rodrigues Bonito
Recruiting
Centro Integrado de Pesquisa Clinica
São José do Rio Preto, Brazil
Carlos Eduardo Miguel
Recruiting
Hospital Bp
São Paulo, Brazil
Danielle Leão Cordeiro de Farias
Recruiting
Hospital Santa Marcelina
São Paulo, Brazil
Patricia de Paulo Giacon
Recruiting
Hospital Da Clinicas Da Faculdade de Medicina Da Usp
São Paulo, Brazil
Raphael Costa Bandeira de Melo
Recruiting

Canada

Royal Victoria Hospital-Montreal
Montreal, Canada
Terminated
Hopital de L'Enfant Jesus
Québec, Canada
Robert Delage
Recruiting
Cancer Care Manitoba
Winnipeg, Canada
Active, not recruiting

Chile

Cecim Biocinetic
Santiago, Chile
Active, not recruiting
Inmunocel
Santiago, Chile
Active, not recruiting
Sociedad de Investigaciones Médicas Limitada
Temuco, Chile
Eduardo Yañez
Recruiting
Centro de Investigaciones Clínicas Viña del Mar (cic)
Viña del Mar, Chile
Active, not recruiting

China

Hunan Cancer Hospital
Changsha, China
Active, not recruiting
the Second Xiangya Hospital of Central South University
Changsha, China
Active, not recruiting
Southern Medical University Nanfang Hospital
Guangzhou, China
Xutao Guo
Recruiting
Sun Yat-Sen University Cancer Center
Guangzhou, China
He Huang
Recruiting
Hainan General Hospital
Haikou, China
Active, not recruiting
First Affiliated Hosp of College of Med, Zhejiang University
Hangzhou, China
Jie Jin
Recruiting
the Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, China
Active, not recruiting
Anhui Provincial Hospital
Hefei, China
Xingbing Wang
Recruiting
the Second Hospital of Anhui Medical University
Hefei, China
Zhai Zhimin
Recruiting
Jiangxi Provincial Cancer Hospital
Nanchang, China
Active, not recruiting

103 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study — it may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 22 Jul 2022
Primary completion: 31 Oct 2027
Completion: 31 Jan 2028
Last update posted: 17 Jun 2026
Registered enrollment: 737
Registry id: NCT05254743

Cross-registrations

EU-CTR / CTIS (EudraCT)2023-507699-38-00

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 12 Jul 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.