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Clinical trialNCT05256641RecruitingPhase 1/PHASE2Interventional

Acalabrutinib Maintenance for the Treatment of Patients With Large B-cell Lymphoma

SponsorJonsson Comprehensive Cancer CenterEnrollment24Diffuse Large B-Cell LymphomaHigh-grade B-cell LymphomaSecondary Central Nervous System LymphomaTransformed Lymphoma
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This phase Ib/II trial studies the side effects and efficacy of maintenance acalabrutinib following cellular therapy in treating patients with large B-cell lymphoma at very high risk of the cancer coming back. Acalabrutinib is a small molecular inhibitor that may interfere with the ability of cancer cells to grow and spread.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

3 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Ucla / Jonsson Comprehensive Cancer Center

    Los Angeles, California, United States

    Caspian Oliai, MD
    Recruiting
  • University of California Davis Comprehensive Cancer Center

    Sacramento, California, United States

    Joseph M. Tuscano
    Recruiting
  • University of Oklahoma

    Oklahoma City, Oklahoma, United States

    Matthew J. Wieduwilt
    Not, yet, recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Acalabrutinib →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
23 Jan 2023
Primary completion
31 Jan 2027
Completion
31 Jan 2028
Last update posted
10 Mar 2026
Registered enrollment
24
Registry id
NCT05256641
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.