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Clinical trialNCT05267886RecruitingPhase 4Interventional

CAPITAL DOREMI 2: Inotrope Versus Placebo Therapy for Cardiogenic Shock

SponsorOttawa Heart Institute Research CorporationEnrollment346Shock, Cardiogenic
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The investigators are interested in determining if there is a meaningful benefit from the use of medications purported to increase the pumping function of the heart (i.e. inotropes) among critically ill patients admitted to the Cardiac Intensive Care Unit (CICU). To do this, the investigators will conduct a multi-centre, double blind, randomized control trial with patients who are deemed to require these medications by their treating physician to one of the two most commonly used agents in Canada (Milrinone or Dobutamine) or placebo. Each patient will be closely monitored by their healthcare team. The dose of medication will be adjusted according to each patients' clinical status. After 12 hours, the participants will move to open label treatment and any continued use of inotropes will be at the discretion of their treating physician.

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

3 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Canada
  • Hamilton Health Sciences

    Hamilton, Ontario, Canada

    Craig Ainsworth, MDEmilie Belley-Cote, MDFaizan Amin, MDRichard Whitlock, MD
    Recruiting
  • University of Ottawa Heart Institute

    Ottawa, Ontario, Canada

    Pietro Di Santo, MDRebecca Mathew, MD
    Recruiting
United States
  • Mayo Clinic

    Rochester, Minnesota, United States

    Benjamin M Hibbert, MD, PhDJacob C Jentzer, MD
    Not, yet, recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
5 Mar 2022
Primary completion
31 Dec 2026
Completion
31 Dec 2026
Last update posted
1 May 2026
Registered enrollment
346
Registry id
NCT05267886

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.