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Clinical trialNCT05287568RecruitingPhase 1Interventional

CC-486 and Venetoclax for Acute Myeloid Leukemia

SponsorUniversity of Colorado, DenverEnrollment35AML
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is an open label, dose escalation Phase I single institution pilot study for relapsed and refractory AML patients using CC-486 (oral azacitidine) with venetoclax. At the completion of dose escalation and after establishment of the MTD or recommended dose of CC-486 with venetoclax, an expansion phase will commence, using venetoclax with the MTD of CC-486 in relapsed/refractory patients.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

2 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • Cu Anschutz Medical Campus

    Aurora, Colorado, United States

    Recruiting
  • University of Colorado Hospital

    Aurora, Colorado, United States

    Brad Haverkos, MDChristine McMahon, MDClay Smith, MDDaniel Pollyea, MDDaniel Sherbenou, MDJagar Jasem, MDJonathan Gutman, MDJorge Urrea, MDManali Kamdar, MDMarc Schwartz, MDMaria Amaya, MD PhDMathew Angelos, MDPeter Forsberg, MDSteven Bair, MD
    Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

CC-486Venetoclax →
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
19 Dec 2022
Primary completion
23 Mar 2027
Completion
31 Mar 2029
Last update posted
15 Jan 2026
Registered enrollment
35
Registry id
NCT05287568
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.