Clinical trialNCT05303519RecruitingPhase 3Interventional

SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance)

SponsorNuvation Bio Inc.Enrollment365Astrocytoma, Grade IVAstrocytoma, IDH-Mutant, Grade 2Astrocytoma, IDH-Mutant, Grade 3Astrocytoma, IDH-Mutant, Grade 4GliomaIDH1-mutant Glioma+2 more conditions

View the registry record on ClinicalTrials.gov

Summary

The registered summary isn't in our current data snapshot. Read it on the ClinicalTrials.gov record ↗. Why? →

Investigators

No overall officials are registered on this study record. Site-level investigators, where published, appear with their sites below. Why? →

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

57 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia

St Vincents Hospital Sydney (kinghorn)
Darlinghurst, New South Wales, Australia
Subotheni Thavaneswaran, MD
Recruiting
Royal North Shore Hospital
Saint Leonards, New South Wales, Australia
Helen Wheeler, MD
Recruiting
Royal Brisbane and Women'S Hospital
Herston, Queensland, Australia
Zarnie Lwin, MD
Recruiting
Peter Maccallum Cancer Centre
Melbourne, Victoria, Australia
Jim Whittle, MD
Recruiting
the Alfred
Melbourne, Victoria, Australia
Lucy Gately, MD
Recruiting
Sir Charles Gairdner Hospital
Nedlands, Western Australia, Australia
Wee Chin, MD
Not, yet, recruiting

China

Beijing Tiantan Hospital, Capital Medical University
Beijing, Beijing Municipality, China
Xiaohui Ren, MD
Recruiting
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China
Wenbin Ma, MD
Recruiting
Sanbo Brain Hospital, Capital Medical University
Beijing, Beijing Municipality, China
Junping Zhang, MD
Recruiting
Xuanwu Hospital, Capital Medical University
Beijing, Beijing Municipality, China
Qingtang Lin, MD
Recruiting
the First Affiliated Hospital of Fujian Medical University
Fuzhou, Fujian, China
Dezhi Kang, MD
Recruiting
Sun Yat-Sen University Cancer Center
Guangzhou, Guangdong, China
Zhongping Chen, MD
Recruiting
Xiangya Hospital of Central South University
Changsha, Hunan, China
Zhixiong Liu, MD
Recruiting
Huashan Hospital Affiliated To Fudan University
Shanghai, Shanghai Municipality, China
Ying Mao, MD
Recruiting
West China Hospital of Sichuan University
Chengdu, Sichuan, China
Yanhui Liu, MD
Recruiting

United States

University of Alabama
Birmingham, Alabama, United States
Luis Nabors, MD
Recruiting
Mayo Clinic - Arizona
Phoenix, Arizona, United States
Shannon Fortin Ensign, MD
Recruiting
St. Joseph'S Hospital and Medical Center
Phoenix, Arizona, United States
Yoshie Umemura, MD
Recruiting
University of California San Diego
La Jolla, California, United States
David Piccioni, MD
Not, yet, recruiting
University of California, Los Angeles
Los Angeles, California, United States
Robert Chong, MD
Recruiting
Hoag Memorial Hospital Presbyterian
Newport Beach, California, United States
Simon Khagi, MD
Recruiting
Stanford University
Palo Alto, California, United States
Seema Nagpal, MD
Recruiting
University of California
San Francisco, California, United States
John De Groot, MD
Recruiting
University of Colorado Health Cancer Care
Aurora, Colorado, United States
Denise Damek, MD
Recruiting
Yale University
New Haven, Connecticut, United States
Nicholas Blondin, MD
Recruiting
University of Florida Health
Gainesville, Florida, United States
Ashley Ghiaseddin, MD
Recruiting
Mayo Clinic - Florida
Jacksonville, Florida, United States
Wendy Sherman, MD
Recruiting
University of Miami Health
Miami, Florida, United States
Macarena de la Fuente, MD
Recruiting
Orlando Health Cancer Institute
Orlando, Florida, United States
Alfredo Voloschin, MD
Recruiting
University of Chicago
Chicago, Illinois, United States
Lauren Singer, MD
Not, yet, recruiting
Indiana University
Indianapolis, Indiana, United States
Kathryn Nevel, MD
Recruiting
University of Kansas Medical Center
Kansas City, Kansas, United States
Tolga Tuncer, MD
Recruiting
Dana-Farber Cancer Institute
Boston, Massachusetts, United States
David Reardon, MD
Recruiting
Massachusetts General Hospital
Boston, Massachusetts, United States
Julie Miller, M.D.
Recruiting
Henry Ford Hospital
Detroit, Michigan, United States
Tobias Walbert, MD
Recruiting
Mayo Clinic - Rochester
Rochester, Minnesota, United States
Eva Galanis, MD
Recruiting
Washington University
St Louis, Missouri, United States
Omar Butt, MD
Recruiting
Billings Clinic
Billings, Montana, United States
Matthew Smith-Cohn, MD
Recruiting
Rutgers Cancer Institute
New Brunswick, New Jersey, United States
Morana Vojnic, MD
Recruiting
Columbia University Medical Center
New York, New York, United States
Fabio Iwamoto, MD
Recruiting

17 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

PlaceboSafusidenib →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 5 Jun 2023
Primary completion: 1 Dec 2028
Completion: 1 Dec 2030
Last update posted: 1 Jul 2026
Registered enrollment: 365
Registry id: NCT05303519

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 12 Jul 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.