Clinical trialNCT05361720RecruitingPhase 2Interventional

Genetic Testing to Select Therapy for the Treatment of Advanced or Metastatic Kidney Cancer, OPTIC RCC Study

SponsorVanderbilt-Ingram Cancer CenterEnrollment54Advanced Clear Cell Renal Cell CarcinomaMetastatic Clear Cell Renal Cell CarcinomaStage III Renal Cell Cancer AJCC v8Stage IV Renal Cell Cancer AJCC v8

View the registry record on ClinicalTrials.gov

Summary

The registered summary isn't in our current data snapshot. Read it on the ClinicalTrials.gov record ↗. Why? →

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

Brian I Rini, MD
Vanderbilt University/Ingram Cancer Center
Principal InvestigatorKOL profile →
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

6 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

City of Hope National Medical Center
Duarte, California, United States
Sumantra Pal, MD
Recruiting
Chao Family Comprehensive Cancer Center
Orange, California, United States
Nataliya Mar, MD
Recruiting
Cleveland Clinic
Cleveland, Ohio, United States
Moshe Ornstein, MD
Recruiting
University Hospitals Seidman Cancer Center
Cleveland, Ohio, United States
Pedro Barata, MD
Recruiting
Vanderbilt University/ingram Cancer Center
Nashville, Tennessee, United States
Brian I. Rini, MD
Recruiting
University of Texas, Southwestern Medical Center
Dallas, Texas, United States
Tian Zhang, MD
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Cabozantinib →Ipilimumab →Nivolumab →

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 6 Dec 2022
Primary completion: 1 Oct 2026
Completion: 1 Jul 2027
Last update posted: 27 Apr 2026
Registered enrollment: 54
Registry id: NCT05361720

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 12 Jul 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.