Clinical trialNCT05376267RecruitingInterventional

Pediatric Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)

SponsorUniversity of MichiganEnrollment900Cardiac Arrest, Out-Of-HospitalHypothermia, InducedHypoxia-Ischemia, Brain

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

This is a multicenter trial to establish the efficacy of cooling and the optimal duration of induced hypothermia for neuroprotection in pediatric comatose survivors of cardiac arrest. The study team hypothesizes that longer durations of cooling may improve either the proportion of children that attain a good neurobehavioral recovery or may result in better recovery among the proportion already categorized as having a good outcome.

clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

Alex Topjian, MD
Children's Hospital of Philadelphia
Principal Investigator
clinicaltrials.gov ↗
Frank Moler, MD
University of Michigan
Principal Investigator
clinicaltrials.gov ↗
William Meurer, MD
University of Michigan
Principal Investigator
clinicaltrials.gov ↗

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

65 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia

Queensland Children'S Hospital
Brisbane, Queensland, Australia
Adrian Mattke, MD, PhD, FRACP, FCICM
Recruiting
Townsville University Hospital
Douglas, Queensland, Australia
Andrew Clift, FCICM, FACRRM, GMC
Recruiting
Gold Coast University Hospital
Southport, Queensland, Australia
Shane George, BSc MBBS MPH FACEM
Recruiting
Women'S and Children'S Hospital
North Adelaide, South Australia, Australia
Subdodh Ganu, MBBS, MD, FCICM
Recruiting
Monash Medical Centre
Clayton, Victoria, Australia
Meredith Allen, MB.BS, FRACP
Recruiting
Royal Children'S Hospital
Parkville, Victoria, Australia
Warrick Butt, FELSO, FCICM, MBBS
Recruiting
Perth Children'S Hospital
Nedlands, Western Australia, Australia
Simon Erikson, FRACP
Recruiting

Canada

the Hospital for Sick Children
Toronto, Ontario, Canada
Anne-Marie Guerguerian, MD, PhD
Recruiting

New Zealand

Starship Children'S Hospital
Grafton, Auckland, New Zealand
John Beca, FRACP, FCICM
Recruiting

United Kingdom

Bristol Royal Hospital for Children
Bristol, Bristol, United Kingdom
Omar Aziz, MSC, MRCGP, MRCPCH, DGM
Recruiting
Evelina London Children'S Hospital
London, London, United Kingdom
Andrew Nyman, MBBCh
Recruiting
Birmingham Children'S Hospital, United Kingdom
Birmingham, United Kingdom
Hari Krishnan, MD
Recruiting
Leeds Children'S Hospital
Leeds, United Kingdom
Jo Lumsden, MBBCh
Recruiting

United States

University of Alabama at Birmingham / Children'S of Alabama
Birmingham, Alabama, United States
Michele Kong, MD
Recruiting
Phoenix Children'S Hospital
Phoenix, Arizona, United States
F. Anthony Willyerd, MD
Recruiting
Banner University Medical Center - Tucson
Tucson, Arizona, United States
Completed
Memorial Health - Miller Children'S and Women'S Hospital of Long Beach
Long Beach, California, United States
Christopher Babbitt, MD
Recruiting
Children'S Hospital of Los Angeles
Los Angeles, California, United States
Recruiting
University of California Los Angeles (ucla) Mattel Children'S Hospital
Los Angeles, California, United States
Anil Sapru, MD
Recruiting
University of California - Oakland / Ucsf Benoiff Children'S Hospital Oakland
Oakland, California, United States
Natalie Cvijanovich, MD
Recruiting
Children'S Hospital of Orange County
Orange, California, United States
Adam Schwarz, MD
Recruiting
University of California, Davis
Sacramento, California, United States
Heather Siefkes, MD
Recruiting
University of California - San Francisco (ucsf) Benioff Children'S Hospital San Francisco
San Francisco, California, United States
Patrick McQuillen, MD
Recruiting
Stanford
Santa Clara, California, United States
Tim Cornell, MD
Recruiting
University of Florida (uf) Health Shands Children'S Hospital
Gainesville, Florida, United States
Shruthi Mahadevaiah, MD
Recruiting
University of Miami
Miami, Florida, United States
Jennifer Munoz Pareja, MD
Recruiting
Johns Hopkins All Children'S Hospital
St. Petersburg, Florida, United States
Nathan Dean, MD
Recruiting
Ann & Robert Lurie Children'S Hospital of Chicago
Chicago, Illinois, United States
Craig Smith, MD
Recruiting
Comer Children'S Hospital, University of Chicago
Chicago, Illinois, United States
Casey Stulce, MD
Recruiting
Children'S Hospital of Illinois
Peoria, Illinois, United States
Sandeep Tripathi, MD
Recruiting
Riley Children'S Health
Indianapolis, Indiana, United States
Matthew Yuknis, MD
Recruiting
University of Iowa, Carver College of Medicine
Iowa City, Iowa, United States
Kari Wellnitz, MD
Recruiting
Johns Hopkins Medicine Children'S Center
Baltimore, Maryland, United States
Caitlin O'Brien, MD, MPH
Recruiting
University of Maryland Children'S Hospital
Baltimore, Maryland, United States
Siddhartha Dante, MD
Recruiting
Massgeneral Hospital for Children
Boston, Massachusetts, United States
Sarah Murphy, MD
Recruiting
University of Michigan Cs Mott Children'S Hospital
Ann Arbor, Michigan, United States
Ryan Barbaro, MD
Recruiting
Children'S Hospital of Michigan
Detroit, Michigan, United States
Kathleen Meert, MD
Recruiting
University of Minnesota Fairview Masonic Children'S Hospital
Minneapolis, Minnesota, United States
Withdrawn
Washington University / St. Louis Children'S Hospital
St Louis, Missouri, United States
Stuart Friess, MD
Recruiting
University of Nebraska Medical Center
Omaha, Nebraska, United States
Alyson Baker, MD MS
Recruiting

25 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 5 Aug 2022
Primary completion: 31 Mar 2028
Completion: 31 Mar 2028
Last update posted: 14 Oct 2026
Registered enrollment: 900
Registry id: NCT05376267

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.