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Clinical trialNCT05382208Active, not recruitingPhase 2Interventional

Doxycycline for Emphysema in People Living With HIV (The DEPTH Trial)

SponsorWeill Medical College of Cornell UniversityEnrollment133EmphysemaHIV
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

The purpose of this study is to determine if doxycycline will reduce progression of emphysema in people living with HIV. The secondary objectives are to examine the effects of doxycycline on change in quantity of emphysema, six minute walk distance, patient reported outcomes, ratio of forced expiratory volume in 1 second and forced vital capacity. Secondary objectives will also describe the safety and tolerability of doxycycline and determine if doxycycline is associated with development of antibiotic-resistant bacterial infections.
clinicaltrials.gov ↗

Investigators

The overall officials registered on this study. Names that resolve to a findmyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

20 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States
  • University of Alabama at Birmingham

    Birmingham, Alabama, United States

  • University of California Los Angeles

    Los Angeles, California, United States

  • University of California San Diego

    San Diego, California, United States

  • Miami University

    Miami, Florida, United States

  • Emory University

    Atlanta, Georgia, United States

  • Tulane University

    New Orleans, Louisiana, United States

  • Johns Hopkins University School of Medicine

    Baltimore, Maryland, United States

  • Massachusetts General Hospital

    Boston, Massachusetts, United States

  • Washington University School of Medicine

    St Louis, Missouri, United States

  • Suny Downstate Medical School

    Brooklyn, New York, United States

  • Weill Cornell Medicine

    New York, New York, United States

  • University of North Carolina

    Chapel Hill, North Carolina, United States

  • Duke University School of Medicine

    Durham, North Carolina, United States

  • University of Cincinnati College of Medicine

    Cincinnati, Ohio, United States

  • Case Western University

    Cleveland, Ohio, United States

  • Ohio State University

    Columbus, Ohio, United States

  • Temple University

    Philadelphia, Pennsylvania, United States

  • University of Pittsburgh

    Pittsburgh, Pennsylvania, United States

  • University of Texas, Mcgovern Medical School

    Houston, Texas, United States

  • University of Washington

    Seattle, Washington, United States

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

Doxycycline →Placebo
Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
22 Aug 2022
Primary completion
28 Feb 2027
Completion
28 Feb 2027
Last update posted
26 Jan 2026
Registered enrollment
133
Registry id
NCT05382208
clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.