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Clinical trialNCT05388708RecruitingObservational

ARDS in Children and ECMO Initiation Strategies Impact on Neurodevelopment (ASCEND)

SponsorUniversity of MichiganEnrollment550Acute Respiratory Distress SyndromeExtracorporeal Membrane Oxygenation
View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

ASCEND researchers are partnering with families of children who receive extracorporeal membrane oxygenation (ECMO) after a sudden failure of breathing named pediatric acute respiratory distress syndrome (PARDS). ECMO is a life support technology that uses an artificial lung outside of the body to do the lung's work. ASCEND has two objectives. The first objective is to learn more about children's abilities and quality of life among ECMO-supported children in the year after they leave the pediatric intensive care unit. The second objective is to compare short and long-term patient outcomes in two groups of children: one group managed with a mechanical ventilation protocol that reserves the use of extracorporeal membrane oxygenation (ECMO) until protocol failure to another group supported on ECMO per usual care.

Investigators

The overall officials registered on this study. Names that resolve to a FindMyKOL profile link to it; the rest are shown as registered.

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

95 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

Australia
  • the Royal Children'S Hospital Melbourne

    Melbourne, Australia

  • Perth Children'S Hospital

    Perth, Australia

  • Queensland Children'S Hospital

    South Brisbane, Australia

  • the Children'S Hospital at Westmead

    Westmead, Australia

Canada
  • Stollery Children'S Hospital

    Edmonton, Alberta, Canada

  • the Hospital for Sick Children

    Toronto, Ontario, Canada

Chile
  • Pontificia Universidad

    Santiago, Chile

Colombia
  • Fundacion Cardiovascular de Colombia

    Floridablanca, Colombia

Italy
  • Istituto Giannina Gaslini

    Genoa, Italy

New Zealand
  • Starship Children'S Hospital

    Grafton, Aukland, New Zealand

Portugal
  • Hospital de Santa Maria

    Lisbon, Portugal

Spain
  • Children'S Hospital and Vall D' Hebron Women'S Hospital

    Barcelona, Spain

  • Sant Joan de Deu Barcelona Hospital

    Barcelona, Spain

  • Hospital Gregorio Maranon

    Madrid, Spain

Sweden
  • Ecmo Centrum Karolinska

    Stockholm, Sweden

United Kingdom
  • Royal Hospital for Children

    Glasgow, United Kingdom

  • Leicester Children'S Hospital

    Leicester, United Kingdom

  • Alder Hey Children'S Hospital

    Liverpool, United Kingdom

  • Evelina London Children'S Hospital

    London, United Kingdom

  • Great Ormond Street Hospital for Children

    London, United Kingdom

  • Royal Brompton Hospital

    London, United Kingdom

  • Freeman Hospital

    Newcastle upon Tyne, United Kingdom

  • Southampton Children'S Hospital

    Southampton, United Kingdom

United States
  • Children'S of Alabama

    Birmingham, Alabama, United States

  • Phoenix Children'S Hospital

    Phoenix, Arizona, United States

  • Arkansas Children'S Hospital

    Little Rock, Arkansas, United States

  • Loma Linda University Children'S Hospital

    Loma Linda, California, United States

  • Ucla Mattel Children'S Hospital

    Los Angeles, California, United States

  • Valley Children'S Hospital

    Madera, California, United States

  • Ucsf Benioff Children'S Hospital Oakland

    Oakland, California, United States

  • Children'S Hospital of Orange County

    Orange, California, United States

  • Lucile Packard Children'S Hospital Stanford

    Palo Alto, California, United States

  • Ucsf Benioff Children'S Hospital - San Francisco

    San Francisco, California, United States

  • Children'S Hospital Colorado

    Aurora, Colorado, United States

  • Connecticut Children'S Medical Center

    Hartford, Connecticut, United States

  • Yale New Haven Children'S Hospital

    New Haven, Connecticut, United States

  • Nemours Children'S Hospital, Delaware

    Wilmington, Delaware, United States

  • Uf Health Shands Children'S Hospital

    Gainesville, Florida, United States

  • Nemours Children'S Hospital, Florida

    Orlando, Florida, United States

  • Orlando Health Arnold Palmer Hospital for Children

    Orlando, Florida, United States

55 more sites on the registry record.ClinicalTrials.gov ↗

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

No drug or biological interventions are in our data for this study. It may test a procedure, device or behavioral intervention, or the intervention list isn't in our current snapshot. See the registry record ↗. Why? →

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start
4 Feb 2021
Primary completion
30 Jun 2027
Completion
30 Sept 2027
Last update posted
14 Jul 2026
Registered enrollment
550
Registry id
NCT05388708

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 4 Nov 2026. Registry facts are shown as registered by the study sponsor; FindMyKOL does not interpret them.