Clinical trialNCT05390892RecruitingPhase 4Interventional

PREvention of CardIovascular and DiabEtic kidNey Disease in Type 2 Diabetes

SponsorBrigham and Women's HospitalEnrollment6,000ASCVDType2Diabetes

View the registry record on ClinicalTrials.gov

Summary

The lay summary the sponsor registered on ClinicalTrials.gov.

PRECIDENTD is a randomized, open label, pragmatic clinical trial designed to compare rates of the total number of cardiovascular, kidney, and death events among two alternative treatments for patients with type 2 diabetes (T2D) and either established atherosclerotic cardiovascular disease (ASCVD) or at high risk for ASCVD. To accomplish this objective, we will randomly assign 6,000 patients with established T2D and ASCVD or high-risk for ASCVD in a 1:1 allocation to sodium-glucose cotransporter-2 inhibitor (SGLT2i) or glucagon-like peptide-1 receptor agonists (GLP-1RA). Participants will be followed for the occurrence of the trial primary endpoint of the total (first and recurrent) number of episodes of myocardial infarction (MI), stroke, arterial revascularization, hospitalization for heart failure, development of end-stage kidney disease, kidney transplantation, and mortality, counting all events from randomization until end of study.

clinicaltrials.gov ↗

Investigators

No overall officials are registered on this study record. Site-level investigators, where published, appear with their sites below. Why? →

A profile link is shown only when the registered name resolves to a person record with a confident, namesake-checked match; ambiguous names stay unlinked.

Sites

36 registered facilities, with the per-site recruitment status where the registry publishes one. ClinicalTrials.gov does not publish per-site enrollment counts.

United States

Longwood Research Llc
Huntsville, Alabama, United States
Saadat Ansari, MD
Recruiting
Honorhealth Research & Innovation Institute
Scottsdale, Arizona, United States
Tabitha Moe, MD FACC
Recruiting
Eastside Clinical Research Associates
Los Angeles, California, United States
Enrique J Gonzalez, MD
Recruiting
Kendall South Medical Center, Inc
Miami, Florida, United States
Enrique Vazquez Escarpanter, MDRafael Chiong, MD
Recruiting
South Florida Research Solutions, Llc
Pembroke Pines, Florida, United States
Dennis Spiller, DOJulio Tallet, MD
Recruiting
Nsc Research, Inc.
Johns Creek, Georgia, United States
Dhaval Shah, MDNarendra Singh, MDTaylor Mabe, NP-C
Recruiting
Herman Clinical Research
Suwanee, Georgia, United States
Amit Narayan, MDLee Herman, MD
Recruiting
University of Illinois Chicago
Chicago, Illinois, United States
Brian Layden, MDYuval Eisenberg, MD
Recruiting
Rush University Medical Center
Hinsdale, Illinois, United States
Ankitaben Han, MD, MSJill K Marcus, MDSameer Panjwani, MD
Recruiting
University of Iowa
Iowa City, Iowa, United States
Hussain Banu, MBBSJeffrey D Quinlan, MDKorey Kennelty, PharmD, MS, PhD, BCGP
Recruiting
University of Kansas Medical Center
Fairway, Kansas, United States
Ethan Alexander, MDKristin K Grdinovac, MD
Recruiting
Johns Hopkins School of Medicine
Baltimore, Maryland, United States
Dan Ford, MDMaya Venkataramani, MD
Recruiting
Medstar Health Research Institute - Good Samaritan Hospital
Baltimore, Maryland, United States
Adline Ghazi, MDJean Park, MD
Recruiting
Medstar Union Memorial Hospital
Baltimore, Maryland, United States
Adline Ghazi, MDSadaf Mustafa, MD
Recruiting
Brigham and Women'S Hospital
Boston, Massachusetts, United States
Marie McDonnell, MD
Recruiting
Umass Chan Medical School
Worcester, Massachusetts, United States
Mark O'Connor, MD
Recruiting
University of Michigan
Ann Arbor, Michigan, United States
David Broome, MD
Recruiting
Essentia Health
Duluth, Minnesota, United States
Catherine Benziger, MD, MPH
Recruiting
University of Minnesota
Minneapolis, Minnesota, United States
Anne Bantle, MD, MSElizabeth Rogers, MD, MAS
Recruiting
University of Missouri-Columbia
Columbia, Missouri, United States
Camilla Manrique Acevedo, MDKatherine Pierce, PhD
Recruiting
University of Nebraska Medical Center
Omaha, Nebraska, United States
Amber Brown Keebler, MDCyrus Desouza, MBBSShubham Agarwal, MBBS
Recruiting
Naomi Berrie Diabetes Center at New York Presbyterian-Columbia University
New York, New York, United States
Jacqueline Lonier, MDNina Suda, MD
Recruiting
Atrium Health Family Medicine Research Department
Charlotte, North Carolina, United States
Emily Manlove Manlove, MDHazel Tapp, PhDLindsay Shade, PA-CMay Royer, MD
Recruiting
Duke University Hospital
Durham, North Carolina, United States
Ranee Chatterjee, MDW. Schuyler Jones, MD
Recruiting
Wooster Heart Group
Wooster, Ohio, United States
Cyril S Ofori, MDToni King, MD
Recruiting
Oregon Health & Science University
Portland, Oregon, United States
Rodica Busui, MD, PhD
Recruiting
Geisinger Medical Center
Danville, Pennsylvania, United States
Alexander Chang, MD, MS, FAHA, FASNAnthony Olson, PharmD, PhD, FAPhAEric Wright, PharmD, MPHWaleed Zafar, MD
Recruiting
Temple University Lewis Katz School of Medicine
Philadelphia, Pennsylvania, United States
Ajaykumar D Rao, MDDaniel J Rubin, MD
Recruiting
Family Care Center at Kent Hospital
Pawtucket, Rhode Island, United States
Caroline Richardson, MDCharles Eaton, MD
Recruiting
Medical University of South Carolina
Charleston, South Carolina, United States
Harsha Karanchi, MDMary Leigh Goodman, DNP, APRN, FNP-C
Recruiting
South Carolina Clinical Research, Llc
Orangeburg, South Carolina, United States
Moustafa A Moustafa, MDRadames Zuquello, MD
Recruiting
Vanderbilt University Medical Center
Nashville, Tennessee, United States
Leslee Matheny, MDRussell Rothman, MD
Recruiting
Premier Internal Medicine Associates of Houston
Katy, Texas, United States
Christina BolinNadia Abbasi, MD
Recruiting
North Dallas Research Associates
McKinney, Texas, United States
Ambreen Ashfaque, MDMuhammad Akram Khan, MD
Recruiting
Kidney and Hypertension Specialists, Pllc
Manassas, Virginia, United States
Hanan Ebjad Ebjad, MD, MHSAPriya Chaddah, PA-CRashida Rahman, MD
Recruiting
Medical College of Wisconsin
Milwaukee, Wisconsin, United States
Jake Decker, MDJeffrey Whittle, MD
Recruiting

Site investigator names are published by ClinicalTrials.gov only while a study recruits, so completed studies list sites without them.

Drugs studied

The drug and biological interventions registered on this study, normalized to their RxNorm ingredient where possible.

GLP-1 receptor agonistSGLT2 inhibitor

Linked drugs open the directory filtered to KOLs working with them.clinicaltrials.gov ↗

Registration & key dates

Registry attributes as recorded on the ClinicalTrials.gov study record.

Start: 26 Sept 2022
Primary completion: 1 Mar 2029
Completion: 1 Mar 2029
Last update posted: 13 Apr 2026
Registered enrollment: 6,000
Registry id: NCT05390892

clinicaltrials.gov ↗

Source: ClinicalTrials.gov, via the CTTI AACT database, data as of 24 Aug 2026. Registry facts are shown as registered by the study sponsor; findmyKOL does not interpret them.